Registration Dossier
Registration Dossier
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EC number: 404-800-4 | CAS number: 118832-72-7 IRGANOX L 118
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
For the determination of the bioaccumulation potential three different QSAR calculation have been performed on one structure of the uvcb substance.
(1) CATALOGIC v5.11.2: BCF = 7.29
(2) T.E.S.T. v4.0.1: BCF = 34.69
(3) EPISuite v4.10: BCF = 211 L/kg
According to these results, the substance is not considered to significantly accumulate in organisms.
Furthermore, the substance has a calculated log Kow of 11.6. According to ECHA's guidance on information requirements and chemical safety assessment R.11 (PBT assessment) the BCF of a substance is probably lower than 2000 L/kg if the calculated lo Kow is higher than 10.
Additionally, for the structure used for the calculation of the QSARs the DiamMax-average is 1.98 nm. According to ECHA's R.11 a DiamMax-average of greater than 1.7 nm can be used within a weight-of-evidence approach to show that the substance is not bioaccumulative.
In conclusion, significant accumulation in organisms is not to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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