[No public or meaningful name is available]

Endpoint summary

Description of key information

No constituents of Distillates (Petroleum), steam-cracked, dimerised (C5-12, C10-rich) are considered to be skin sensitisers and do not warrant classification under GHS/CLP.

No data have been found concerning respiratory sensitisation and there are no indications that constituents within Distillates (Petroleum), steam-cracked, dimerised (C5-12, C10-rich) are respiratory allergens.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Additional information:

Data on the components benzene, DCPD and toluene indicate that Distillates (Petroleum), steam-cracked, dimerised (C5-12, C10-rich) is considered not to be skin or respiratory sensitiser according to GHS/CLP.

3a,4,7,7a-tetrahydro-4,7-methanoindene (DCPD, dicyclopentadiene; does not warrant classification under GHS/CLP):

In Buehler test, according to OECD guideline 406 study in female guinea pigs, DCPD was considered to be a non-sensitiser to guinea pig skin (Safepharm, 1989).

Benzene (does not warrant classification under GHS/CLP):

Although there are no GLP guideline compliant studies on the skin sensitisation potential of benzene, it was assessed in a mouse ear swelling test (MEST) and a reduced guinea pig maximisation test (GPMT) using neat benzene. None of the mice and none of the guinea pigs showed any evidence of sensitisation (Gad et al, 1986). Additionally, in a study using 25 male volunteers a maximisation test with induction using 50% benzene and challenge with 20% benzene no evidence of skin sensitisation was seen (0/25) (Kligman, 1966).  

 

Toluene (does not warrant classification under GHS/CLP):

A maximisation test in guinea pigs (EU guideline B6 Skin sensitisation) showed that toluene is not a skin sensitiser (NOTOX, 1996).

 

In addition to the data presented above on constituents of the UVCB Distillates (Petroleum), steam-cracked, dimerised (C5-12, C10-rich), data are available for UVCBs with similar compositions – these are also produced via similar manufacturing processes and are rich in DCPD and other cyclic olefins, as well as aromatic compounds. InEPA OTS 798.4100 (Skin Sensitisation) guideline studies the following UVCBs: E000144700 (CAS 68516-20-1), E000044146 (CAS 68478-10-4) and E000044012 (CAS 68478-10-4) were shown to be non-sensitisers and do no warrant classification under GHS/CLP (Lyondell 1990r, q and p).

 

No data have been found concerning respiratory sensitisation and there are no indications that constituents within Distillates (Petroleum), steam-cracked, dimerised (C5-12, C10-rich) are respiratory allergens.

Respiratory sensitisation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information:

No specific animal or human data have been found with regard to respiratory sensitisation for any constituents of Distillates (Petroleum), steam-cracked, dimerised (C5-12, C10-rich).

Justification for classification or non-classification

There are sufficient data on E000044012 [CAS 68478-10-4]; E000044146 [CAS 68478-10-4]; E000144700 [CAS 68516-20-1] and on other constituents to indicate that Distillates (Petroleum), steam-cracked, dimerised (C5-12, C10-rich) is not a skin sensitiser. Although there are no specific data on respiratory sensitisation of Distillates (Petroleum), steam-cracked, dimerised (C5-12, C10-rich), the marker substances suggest there are no indications that constituents within Distillates (Petroleum), steam-cracked, dimerised (C5-12, C10-rich) are respiratory allergens. It is proposed that no classification is warranted for these end-points under GHS/CLP.