Registration Dossier
Registration Dossier
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EC number: 700-363-1 | CAS number: 1335203-20-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
In vitro studies were carried out for both the skin and eye irritation studies and results showed that Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes did not cause any irritation. The design of the study does not allow for the derivation of an acute DNEL based on local effects or systemic effects. Therefore, it is deemed irrelevant to derive a DN(M)EL.
Based on the tonnage band of use of Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes, no data was generated to address repeated exposure and it is not deemed necessary to carry out a full exposure assessment for this substance. Therefore, a long term DN(M)EL for local and/or systemic effect is not established.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - General Population
In vitro studies were carried out for both the skin and eye irritation and results showed that Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes did not cause any irritation. The design of the study does not allow for the derivation of an acute DNEL based on local effects or systemic effects. Therefore, it is deemed irrelevant to derive a DN(M)EL.
Based on the tonnage band of use of Hydrolysed reaction products of furan-2,5-dione and C15-18-(linear and branched)-alkenes, no data was generated to address repeated exposure and it is not deemed necessary to carry out a full exposure assessment for this substance. Therefore, a long term DN(M)EL for local and/or systemic effect is not established.
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