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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Reason / purpose:
data waiving: supporting information
Qualifier:
equivalent or similar to
Guideline:
other: OECD Guideline 105 (Water Solubility)
Version / remarks:
A method has been proposed by Thomas and Burosse to improve the current OECD 105 Water Solubility test design for poorly water soluble liquids by incorporating a portion of another OECD guideline (OECD 123) This method is very similar to a previous method used by Varaprath et al to determine the solubility of several poorly soluble permethylsiloxanes. The test article was anticipated to be so poorly soluble, that the current methods listed in OECD 105 are inappropriate
Deviations:
yes
Remarks:
Minor deviations were noted but these did not have an impact on the overall study
GLP compliance:
yes
Type of method:
slow-stirring method
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Remarks on result:
not determinable because of methodological limitations
Remarks:
The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g.
Details on results:
The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g.

The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g, hence partition co-efficient is not determinable.

Conclusions:
The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g, hence partition co-efficient is not determinable.
Executive summary:

The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g, hence partition co-efficient is not determinable.

Description of key information

The aqueous solubility of HES 10108 was investigated in accordance with EPA (TSCA) Good Laboratory Practices 40 CFR Part 792. Test vessels were setup similar to the slow stirring method (OECD 123) to account for anticipated poor water solubility. Water samples were concentrated using solid phase extraction and analyzed by GC-FID. The aqueous solubility was found to be less than the method detection limit of 7.17 ng/g, hence partition co-efficient is not determinable.

Key value for chemical safety assessment

Additional information