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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Principles of method if other than guideline:
not applicable
GLP compliance:
yes
Type of method:
other: Knudsen cell effusion method
Specific details on test material used for the study:
Name: HESI0108
Physical state: Light yellow liquid
Sponsor batch: 0008624816
Purity: 99.3 %
Arrival date: 14 December 2016
Expiry date: 25 August 2017
Storage conditions: Room temperature (15 to 30°C)
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 Pa

Vapour Pressure

The thermal analysis revealed that HES 10108 was thermally stable up to 210°C.

Test 1

The temperature range for this test was 20 to 159°C, this established that the vapour pressure was too low to be measured below 96°C, after initial weight losses at the lower temperatures,

possibly due to solvent loss/impurities.

Test 2

The temperature range for this test was 125 to 156°C. The results from this test suggested that the results might be on the curved part of the Ln (VP) vs 1/T graph, which could possibly explain the results in Test 1.

Test 3

The temperature range was 94 to 131°C, this gave rise to some quite erratic results, the initial loss at 94°C was due to the same reasons as in Test 1, the temperature was increased when the vapour pressure went below 1 x 10 (-4) Pa.

To exclude outside factors influencing the results; dioctyl phthalate was tested over a similar range to that of this test. This would check that the system pressure display was correct. The vapour pressure at 20°C was 5.9 x 10-6 Pa, compared to 5.9 x 10-6 Pa cited in OPPTS 830.7950. This confirmed that the system pressure display was working correctly.

Test 4 The temperature range was 93 to 123°C. Once the vapour pressure at 93°C had dropped below 1 x 10 (-4) Pa; tests were performed over longer test periods than the previous tests in an attempt to improve consistency. The results for this test were also erratic.

Summary

The results from all the above tests were pooled for temperatures from 96°C (Test 1), 94°C (Test 3) and 94°C (Test 4) where the vapour pressure was lower than 1 x 10 (-4) Pa and then all temperatures up to 159°C for all the tests regardless of the vapour pressure. The combined results gave a good spread of results; from which the vapour pressure at 20 and 25°C could be estimated:

Vapour pressure at 20°C =2.2 x 10(-10) Pa Vapour pressure at 25°C = 5.7 x 10 (-10) Pa

Due to the uncertainty of measurement the accuracy of this result is ±50%, reflecting the nature of a complex mixture of components. IR analysis was performed only at the end of Test 4 and confirmed no degradation over the course of the test this was considered to be indicative of Tests 1 to 3.

Conclusions:
The vapour pressure of HES 10108 was evaluated using OECD guideline 104 and 44012008 EC Method A.4. (Knudsen cell effusion method):
Vapour pressure at 20°C = 2.2 x 10(-10) Pa Vapour pressure at 25°C =5.7 x 10(-10) Pa
The test substance was stable throughout the vapour pressure test.
Executive summary:

The vapour pressure of HES 10108 was evaluated using OECD guideline 104 and 44012008 EC Method A.4. (Knudsen cell effusion method):

Vapour pressure at 20°C = 2.2 x 10(-10) Pa Vapour pressure at 25°C =5.7 x 10(-10) Pa

The test substance was stable throughout the vapour pressure test.

Description of key information

The vapour pressure of HES 10108 was evaluated using OECD guideline 104 and 44012008 EC Method A.4. (Knudsen cell effusion method):

Vapour pressure at 20°C = 2.2 x 10(-10) Pa Vapour pressure at 25°C =5.7 x 10(-10) Pa

The test substance was stable throughout the vapour pressure test.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information