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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Triphenyl phosphite, a new allergen in polyvinylchloride gloves
Author:
Katri Suuronen, Maria Pesonen, Maj-Len Henriks-Eckerman and Kristiina Aalto-Korte
Year:
2012
Bibliographic source:
Contact Dermatitis, 68, 42–49

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Background.

Contact allergy to polyvinylchloride (PVC) gloves has been reported relatively seldom. In spring 2011, 5 of our patients had patch test reactions to PVC gloves. We obtained a collection of PVC raw materials from industrial producers and suppliers of chemical compounds to be patch tested on patientswith suspected PVC glove contact allergy.

Objectives.

To report the first results of these new test substances.

Methods.

The patients were patch tested with the newly obtained test substances, plastics and glues series, and isocyanates and isocyanate prepolymers. We analysed nine PVC glove samples for triphenyl phosphate and its derivatives.

Results.

Twopatients reacted to a technical PVC antioxidant and one of its components, triphenyl phosphite (TPP). Contact allergy to TPP was very strong in 1 patient, and was the main cause of her hand dermatitis, whereas the other patient also had other contact allergies explaining her symptoms. Three patients reacted to their PVC gloves, but the specific allergen was not identified. Six PVC glove samples contained TPP at concentrations of 0.004–0.099%. TPP transforms into triphenyl phosphate during storage.

Conclusions. TPP represents a new allergen in PVC gloves. It was detected in several PVC gloves in fairly high concentrations.

Applicant's summary and conclusion