Triphenyl phosphite

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Triphenyl phosphite

EC Number:

202-908-4

EC Name:

Triphenyl phosphite

Cas Number:

101-02-0

Molecular formula:

C18H15O3P

IUPAC Name:

triphenyl phosphite

Details on test material:

- Name of test material (as cited in study report): Triphenyl Phosphite
- Lot/batch No.: TPPX-Z18-04080A (Borg Warner)

Test animals

Species:

rat

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200-210 average weights
- Housing: in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR Part 3.

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: plexiglass exposure chamber
- Exposure chamber volume: 260 l
- Method of holding animals in test chamber:
- Source and rate of air: 20 liters per minute
- System of generating particulates/aerosols: six jet Collision nebulizer (BGI Incorporated, Waltham, Mass.). The air was passed through a desleant prior to being passed through the test material
- Method of particle size determination: Andersen Sampler cascade impactor. From these values the mass median diameter of the aerosol was calculated to be 0.73 microns and the concentration was calculated to be 0.10 mg/L.
- Temperature, humidity, pressure in air chamber: 70°F

Duration of exposure:

1 h

Concentrations:

6.7 mg/liter

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 21
- Frequency of weighing: day 0 and day 21
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 6.7 mg/L air (nominal)

Exp. duration:

1 h

Mortality:

No mortalities occurred.

Clinical signs:

other: No adverse effects were observed during the one hour exposure period. No untoward symptoms were observed during the three week post exposure observation period.

Body weight:

The animals gained weight during the course of the study.

Gross pathology:

Gross pathologic examination revealed nothing remarkable.

Any other information on results incl. tables

Andersen Sampler:

Concentration = 0.24 mg/liter

Particle size = 0.73µ MMD (mass median diameter)

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

Based on the results of this inhalative acute toxicity study in rat, the LC50 was found to be > 6.7 mg/L air. Since the exposure duration was only 1h, the concentrations analysed were too low to conclude on a classification.