Sodium (2-butoxyethoxy)acetate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-08-14

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

adopted on July 27, 1995

Deviations:

no

GLP compliance:

not specified

Type of method:

flask method

Specific details on test material used for the study:

- CAS number: 67990-17-4

Key result

Water solubility:

443.4 g/L

Conc. based on:

test mat.

Incubation duration:

10 min

Temp.:

20 °C

pH:

13.5

Remarks on result:

other: water solubility = 443.4 +/- 21.2 g/L

Details on results:

The individual results differed by 4.8 % for water solubility, which makes tests correct.

Table: Water solubility of the test item

Flask	Shaking duration (h)	Weighted sample in g/2.5 mL	Sum of peak areas of the signals	Water solubility of Mercerol B g/L	Average g/L	Average g/L	Standard deviation
WAT-1	24	3.3174	785716	436.5	450.8	443.4	21.2
WAT-2	24	3.4374	838031	455.6
WAT-3	24	3.2628	850969	460.3
WAT-4	48	3.1413	679992	398.1	419.5
WAT-5	48	1.1374	753898	424.9
WAT-6	48	3.3063	782529	435.4
WAT-7	72	3.0044	808479	444.8	459.9
WAT-8	72	3.2695	871819	468.0
WAT-9	72	3.2821	868554	466.8

Conclusions:

The water solubility of the test item was measured according to OECD TG 105 (flask method) to be 443.4 +/- 21.2 g/L.

Executive summary:

To determine the water solubility of the test item a study according to OECD TG 105 (flask method) was carried out. A preliminary test was made to choose the appopriate method for this determination. In the main test, 9 flasks were prepared. In each flask, about 3 g of the test item were added to 2.5 mL of water. These solutions were shaken for 24, 48 and 72 hours at 20 °C. After each 24 hours interval, 3 flasks were put aside. The samples were filtered through a 0.45 µm filter. The last filtrated solution samples were analysed with HPLC-method. The individual results differed by 4.8% and hence, the tests are regarded correct. The water solubility of the test item was determined to be 443.4 +/- 21.2 g/L.

Description of key information

The water solubility of the substance was measured according to OECD TG 105 (flask method) to be 443.4 g/L at 20 °C and pH = 13.5.

Key value for chemical safety assessment

Water solubility:

443.4 g/L

at the temperature of:

20 °C

Additional information

Key study

To determine the water solubility of the test item a study according to OECD TG 105 (flask method) was carried out. A preliminary test was made to choose the appopriate method for this determination. In the main test, 9 flasks were prepared. In each flask, about 3 g of the test item were added to 2.5 mL of water. These solutions were shaken for 24, 48 and 72 hours at 20 °C. After each 24 hours interval, 3 flasks were put aside. The samples were filtered through a 0.45 µm filter. The last filtrated solution samples were analysed with HPLC-method. The individual results differed by 4.8% and hence, the tests are regarded correct. The water solubility of the test item was determined to be 443.4 +/- 21.2 g/L at 20 °C and pH = 13.5 (Infrapark Baselland AG, 2018).

Supporting information

The water solubility was calculated using MPBVP v1.43 as part of EPISuite v4.11 from US Environmental Protection Agency. Using WSKOW v1.42 the water solubility of the test item was calculated to be 1000 g/L at 25 °C.

Conclusion

Based on the most reliable information (Infrapark Baselland AG, 2018) the water solubility of the test item is considered to be 443.4 g/L at 20 °C and pH = 13.5. This result is supported by a QSAR prediction using WSKOW v1.42 (EPISuite v4.11) as the water solubility of the test item at 25 °C was calculated to be 1000 g/L.