Registration Dossier
Registration Dossier
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EC number: 207-987-9 | CAS number: 504-24-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- A Summary of the Acute Toxicity of 4-Aminopyridine to Birds and Mammals
- Author:
- EDWARD W. SCHAFER, JR., RONALD B. BRUNTON AND DONALD J. CUNNINGHAM
- Year:
- 1 973
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY 26, 532-538 U.S. Bureau of Sport Fisheries and Wildlife, Wildlife Research Center, Denver, Colorado 80225
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Previously unpublished data from the Denver Wildlife Research Center (DWRC) were derived primarily by the po methods described by DeCino et al. (1966), Schafer (1972), and Schafer et aÍ. (1967). Other methods of oral administration included force-feeding synthetic pellets (Pan and Caslick, 1966) or treated grain. Dermal toxicity was determined by the method described by Schafer et al. (1969). All test animals were adults unless noted in the table. LD50 values and 95 0/0 confidence limits were derived by the moving-point interpolation method described by Thompson (1948), Thompson and Weil (1952), and Weil (1952). The 4AP used was technical material of about 95% purity.
Methodology for other data can be found in the cited articles. - GLP compliance:
- not specified
- Test type:
- other: not specified
Test material
- Reference substance name:
- 4-pyridylamine
- EC Number:
- 207-987-9
- EC Name:
- 4-pyridylamine
- Cas Number:
- 504-24-5
- Molecular formula:
- C5H6N2
- IUPAC Name:
- nickel
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 327 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Acute dermal - rabbit LD50 = 327 mg/kg
- Executive summary:
Acute dermal - rabbit LD50 = 327 mg/kg
(toxicology review: EPA TSCA Inventory)
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