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EC number: 238-692-3
CAS number: 14643-87-9
DNEL derived from zinc compounds is the most
conservative. OELs for soluble zinc
compounds represented by zinc chloride are
available. While a detailed scientific
justification for the OELs is not available,
these values have ensured workers safety for
decades which correlates with the DNELs
derived from the human volunteer studies.
Taking a conservative approach it is
proposed that for inhalation exposure, the
existing OEL values are used as the
respective DNEL (1 mg/m3/day). Then, a
correction factor needs to be applied to
take into account the difference in
molecular weights between zinc and zinc
methacrylate: zinc has a molecular weight of
65.38 g/mol. Zinc diacrylate has a molecular
weight of 207.52 g/mol. A proportional rule
is applied: DNEL inh = 1 mg Zn/m3/day x 3.2
= 3.2 mg Zinc diacrylate/m3/day.
The starting point is a repeated dose
toxicity study in rat with zinc sulphate for which the NOAEL was
equivalent to 170 mg zinc diacrylate/kg bw/day.
starting point is a repeated dose toxicity study in rat with zinc
sulphate for which the NOAEL was equivalent to 170 mg zinc diacrylate/kg
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