Registration Dossier
Registration Dossier
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EC number: 238-692-3 | CAS number: 14643-87-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Used in EU risk assessment report for zinc sulphate, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Zinc sulphate
- EC Number:
- 231-793-3
- EC Name:
- Zinc sulphate
- Cas Number:
- 7733-02-0
- IUPAC Name:
- zinc sulfate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- Details on study design:
- observation period of 15 days
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: (equivalent to 45529 mg Zn/kg bw or 1443 mg zinc diacrylate/kg bw)
- Mortality:
- none
- Clinical signs:
- other: no effects
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the study conditions, the dermal LD50 was >2000 mg/kg bw (equivalent to 455 mg Zn/kg bw or 1443 mg zinc diacrylate/kg bw).
- Executive summary:
Zinc sulphate heptahydrate was administered to the skin of five Wistar rats of each sex at 2000 mg/kg bw for 24 h. Animals were observed for 15 days. Clinical signs of toxicity consisted of erythema (grade 1 and 2, of maximum grade 4), scales and/or scabs (scale 1 and 2, of maximum scale 3) in the treated skin area between observation days 2-8. Zinc sulphate was not harmful or toxic via the dermal route. Under the study conditions, the dermal LD50 was >2000 mg/kg bw (equivalent to 455 mg Zn/kg bw or 1443 mg zinc diacrylate/kg bw) (Van Huygevoort, 1999).
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