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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

The fish were exposed to 14C labeled estradiol and additionally to the dilution water (tap water) for a period of 21 days. Two replicate tanks for the
test concentration and one tank for the tap water control were used. After the accumulation phase, the fish were held a futher 7 days for depuration. 40 fish were used for the test solution and 20 for the control group.
The concentration of the test substance in the fish and in the water was determined through both phases of the test. The 14C concentration in the fish was analyzed by liquid scintillation after combustion of aliquots of the fish in samples taken on day 4, 6, 10, 14, 21, 24, and 26.
The 14C concentration in the water was analyzed by liquid scintillation in samples taken on day 4, 6, 10, 14, 21, 24, and 26.


Results: The BCF was 108.8 or 85.9 if lipid normalized (6%). s.

Key value for chemical safety assessment

BCF (aquatic species):
108.8 L/kg ww

Additional information

The study was performed under GLP (report A52549).