Registration Dossier

Administrative data

Description of key information

Skin irritation:

The dermal irritation potential of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor. 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated to be irritating to the skin of New Zealand White rabbits. Based on the estimated result 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) can be considered to be irritating and corrosive to skin and can be classified under the category ˋCategory 2 (irritant)’ as per CLP regulation.

Eye irritation:

The ocular irritation potential of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor. 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated to be not irritating into the eyes of New Zealand White rabbits. Based on the estimated result 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) can be considered to be not irritating to eye and can be classified under the category ˋ Not Classified’ as per CLP regulation.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data is from OECD QSAR toolbox version 3.3 and QMRF report has been attached
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 3.3
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material: 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride
- Molecular formula: C8H9Cl3O
- Molecular weight: 227.517
- Smiles notation: O=C([C@@H]1C(C)(C)[C@@H]1\C=C(/Cl)Cl)Cl
- InChl: 1S/C8H9Cl3O/c1-8(2)4(3-5(9)10)6(8)7(11)12/h3-4,6H,1-2H3
- Substance type: Organic
Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
No data available
Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
15 days
Observation period:
15 days
Number of animals:
No data available
Details on study design:
No data available
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 15 d
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
skin irritating effects were observed.

Estimation method: Takes mode value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

(((((((("a" or "b" or "c" or "d" or "e" )  and ("f" and ( not "g") )  )  and "h" )  and ("i" and ( not "j") )  )  and ("k" and ( not "l") )  )  and "m" )  and "n" )  and ("o" and "p" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Acid Chlorides by US-EPA New Chemical Categories

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Acyl halide OR Alkenyl halide OR Cycloalkane by Organic Functional groups ONLY

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Acyl halide OR Alkenyl halide OR Cycloalkane OR Overlapping groups by Organic Functional groups (nested) ONLY

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Aliphatic Carbon [CH] OR Aliphatic Carbon [-CH2-] OR Aliphatic Carbon [-CH3] OR Carbonyl, aliphatic attach [-C(=O)-] OR Chlorine, olefinic attach [-Cl] OR Miscellaneous sulfide (=S) or oxide (=O) OR Olefinic carbon [=CH- or =C<] OR Tertiary Carbon by Organic functional groups (US EPA) ONLY

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as Acyl chloride OR Acyl halide OR Carbonic acid derivative OR Carboxylic acid derivative OR CO2 derivative (general) OR Halogen derivative by Organic functional groups, Norbert Haider (checkmol) ONLY

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as (!Undefined)Group All Lipid Solubility < 0.01 g/kg by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as (!Undefined)Group C Surface Tension > 62 mN/m OR (!Undefined)Group CN Lipid Solubility < 0.4 g/kg OR (!Undefined)Group CNHal Lipid Solubility < 4 g/kg OR (!Undefined)Group CNHal Lipid Solubility < 400 g/kg OR (!Undefined)Group CNS Surface Tension > 62 mN/m OR Exclusion rules not met OR Group All log Kow < -3.1 OR Group All log Kow > 9 OR Group All Melting Point > 200 C OR Group C Aqueous Solubility < 0.0001 g/L OR Group C Melting Point > 55 C OR Group C Molecular Weight > 350 g/mol OR Group C Vapour Pressure < 0.0001 Pa OR Group CHal log Kow > 4.5 OR Group CHal Melting Point > 65 C OR Group CHal Molecular Weight > 280 g/mol OR Group CN Aqueous Solubility < 0.1 g/L OR Group CN log Kow > 4.5 OR Group CN log Kow > 5.5 OR Group CN Melting Point > 180 C OR Group CN Vapour Pressure < 0.001 Pa OR Group CNHal Aqueous Solubility < 0.001 g/L OR Group CNHal Aqueous Solubility < 0.1 g/L OR Group CNHal Molecular Weight > 370 g/mol OR Group CNHal Molecular Weight > 380 g/mol OR Group CNS log Kow < 0.5 OR Group CNS log Kow < -2 OR Group CNS Melting Point > 120 C OR Group CNS Melting Point > 50 C by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis ONLY

Domain logical expression index: "i"

Referential boundary: The target chemical should be classified as Halogens AND Non-Metals by Groups of elements

Domain logical expression index: "j"

Referential boundary: The target chemical should be classified as Alkali Earth OR Metalloids OR Metals OR Transition Metals by Groups of elements

Domain logical expression index: "k"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 16 - Oxygen O AND Group 17 - Halogens Cl AND Group 17 - Halogens F,Cl,Br,I,At by Chemical elements

Domain logical expression index: "l"

Referential boundary: The target chemical should be classified as Group 15 - Nitrogen N OR Group 16 - Sulfur S OR Group 17 - Halogens F by Chemical elements

Domain logical expression index: "m"

Referential boundary: The target chemical should be classified as Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Carbonyl, aliphatic attach [-C(=O)-] AND Chlorine, olefinic attach [-Cl] AND Miscellaneous sulfide (=S) or oxide (=O) AND Olefinic carbon [=CH- or =C<] AND Tertiary Carbon by Organic functional groups (US EPA) ONLY

Domain logical expression index: "n"

Similarity boundary:Target: CC1(C)C(C=C(Cl)Cl)C1C(=O)Cl
Threshold=40%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "o"

Parametric boundary:The target chemical should have a value of log Kow which is >= 1.98

Domain logical expression index: "p"

Parametric boundary:The target chemical should have a value of log Kow which is <= 4.44

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The test substance 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated to be irritating to the skin of New Zealand White rabbits. Based on the estimated result 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) can be considered to be irritating and corrosive to skin.
Executive summary:

The dermal irritation potential of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor. 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated to be irritating to the skin of New Zealand White rabbits. Based on the estimated result 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) can be considered to be irritating and corrosive to skin and can be classified under the category ˋCategory 2 (irritant)’ as per CLP regulation.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data is from OECD QSAR toolbox version 3.3 and QMRF report has been attached
Qualifier:
according to
Guideline:
other: estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 3.3
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material: 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride
- Molecular formula: C8H9Cl3O
- Molecular weight: 227.517
- Smiles notation: O=C([C@@H]1C(C)(C)[C@@H]1\C=C(/Cl)Cl)Cl
- InChl: 1S/C8H9Cl3O/c1-8(2)4(3-5(9)10)6(8)7(11)12/h3-4,6H,1-2H3
- Substance type: Organic
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
No data available
Vehicle:
not specified
Controls:
yes
Amount / concentration applied:
No data available
Duration of treatment / exposure:
7 days
Observation period (in vivo):
7 days
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No eye irritating effects were observed.

Estimation method: Takes mode value from the 6 nearest neighbours
Domain  logical expression:Result: In Domain

(((((("a" or "b" or "c" or "d" or "e" )  and ("f" and ( not "g") )  )  and ("h" and ( not "i") )  )  and ("j" and ( not "k") )  )  and "l" )  and ("m" and "n" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Acid Chlorides by US-EPA New Chemical Categories

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Acyl halide OR Alkenyl halide OR Cycloalkane by Organic Functional groups ONLY

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Acyl halide OR Alkenyl halide OR Cycloalkane OR Overlapping groups by Organic Functional groups (nested) ONLY

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Aliphatic Carbon [CH] OR Aliphatic Carbon [-CH2-] OR Aliphatic Carbon [-CH3] OR Carbonyl, aliphatic attach [-C(=O)-] OR Chlorine, olefinic attach [-Cl] OR Miscellaneous sulfide (=S) or oxide (=O) OR Olefinic carbon [=CH- or =C<] OR Tertiary Carbon by Organic functional groups (US EPA) ONLY

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as Acyl chloride OR Acyl halide OR Carbonic acid derivative OR Carboxylic acid derivative OR CO2 derivative (general) OR Halogen derivative by Organic functional groups, Norbert Haider (checkmol) ONLY

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as Non binder, without OH or NH2 group by Estrogen Receptor Binding

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as Non binder, MW>500 OR Non binder, non cyclic structure by Estrogen Receptor Binding

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as (!Undefined)Group All Lipid Solubility < 0.01 g/kg by Eye irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "i"

Referential boundary: The target chemical should be classified as (!Undefined)Group CN Lipid Solubility < 0.4 g/kg OR Group All Aqueous Solubility < 0.000005 g/L OR Group All Aqueous Solubility < 0.00002 g/L OR Group All log Kow > 9 OR Group All Melting Point > 200 C OR Group C Aqueous Solubility < 0.0001 g/L OR Group C Aqueous Solubility < 0.0005 g/L OR Group C Melting Point > 55 C OR Group C Molecular Weight > 380 g/mol OR Group CHal Melting Point > 65 C OR Group CN Aqueous Solubility < 0.1 g/L by Eye irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "j"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 16 - Oxygen O AND Group 17 - Halogens Cl AND Group 17 - Halogens F,Cl,Br,I,At by Chemical elements

Domain logical expression index: "k"

Referential boundary: The target chemical should be classified as Group 15 - Nitrogen N OR Group 16 - Sulfur S OR Group 17 - Halogens F by Chemical elements

Domain logical expression index: "l"

Similarity boundary:Target: CC1(C)C(C=C(Cl)Cl)C1C(=O)Cl
Threshold=20%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "m"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.41

Domain logical expression index: "n"

Parametric boundary:The target chemical should have a value of log Kow which is <= 3.2

Interpretation of results:
other: not irritating
Conclusions:
The chemical 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated to be not irritating into the eyes of New Zealand White rabbits.
Executive summary:

The ocular irritation potential of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor. 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was estimated to be not irritating into the eyes of New Zealand White rabbits. Based on the estimated result 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) can be considered to be not irritating to eye and can be classified under the category ˋ Not Classified’ as per CLP regulation.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation:

Various studieshas been investigated for the test chemical3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7)to observe the potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) and its structurally similar read across substancesDicyclopentadiene (CAS no: 77-73-6)and Neodecanoyl chloride (CAS no: 40292-82-8).The predicted data using the OECD QSAR toolbox andDanish QSAR databasehas also been compared with the experimental data and summarized as below;

 

 

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the skin irritation potential was estimated for test chemical3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7).The chemical 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) is estimated to be irritating and corrosive to skin of New Zealand White rabbits.

 

 

According toDanish QSAR database, theskin irritation effects were estimated by using four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra for 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7). Based on estimation, severe skin irritation effects were known when 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) was exposed to rabbit skin.

 

 

In NTRL report (2008),skin irritation study of structurally similar read across substance Dicyclopentadiene (CAS no: 77-73-6) was conducted on three New Zealand White rabbits to observe its irritation efficacy in accordance with OECD Guidelines No. 404 -Acute Dermal irritation /Corrosion which supports the above result.In this study, 0.5ml of Dicyclopentadienewas applied to intact skin locations on the backs of each rabbits for four hours semi-occlusive condition and skin reactions were scored for 7 daysaccording to Draize scoring system. The results were also interpreted according to the E.E.C. Directive of 29 July 1983 83/467/EEC adapting Council Directive 67/548/EEC on the regulations relating to the classification, packaging and labelling of dangerous substances. Well-defined erythema was observed within 3 days of exposure in all animals. Signs of keratinization were observed on day 7. Moderate edema was observed at 24 hours in all animals, and regressed to slight by day 3. No corrosive effects were observed. Since the Primary irritation index of 4.7was obtained,the chemical Dicyclopentadienewas considered to bemoderately irritatingto the skin ofNew Zealand Whiterabbits .

 

 

The above results were further supported by experimental study conducted by OECD SIDS (2008) ofstructurally similar read across substanceNeodecanoyl chloride (CAS no: 40292-82-8) on four rabbits in order to examine the degree of skin irritation caused by the chemical according to OECD Guideline 404 (Acute Dermal Irritancy/Corrosivity Study). About 0.5 ml of the neat test substance was applied to the intact dorsal skin, clipped 24 hrs before treatment, and left in place under an occlusive cover for 1 hour (2 animals) or 4 hours (2 animals). At the end of the exposure period excess Substance was removed and the skin was rinsed and dried. The Skin reactions were examined and scored immediately after patch removal, and 1, 2, and 8 days thereafter. The skin reactions following 1-hr exposure shown below were reversible within 8 days. Necroses developed in both animals after a 4-hr contact period Full skin necrosis was confirmed by pathological examination of the skin after terminal sacrifice.On the basis of observed effects, the chemicalNeodecanoyl chloride (CAS no: 40292-82-8) can be considered as corrosive and irritatingto the skin of rabbits.

 

 

Thus on the basis of available data for thetarget chemical3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) and its structurally similar read across substancesDicyclopentadiene (CAS no: 77-73-6)and Neodecanoyl chloride (CAS no: 40292-82-8),it can be concluded thatchemical 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) is able to cause skin irritation and corrosion and thus considered as irritating.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 2 (irritant)”.

 

 

 

Eye irritation:

In different studies,the test chemical3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) has been investigated for potential for ocular irritationto a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) andits structurally similar read across substances Cyclohexane (CAS No: 110-82-7)and Neodecanoyl chloride (CAS no: 40292-82-8) .The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;

 

 

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the ocular irritation potential was estimated for test chemical3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7).The chemical 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) is estimated to be not irritating to eye of New Zealand White rabbits.

 

 

 

The NTRL (1986) and European Communities (2004) reported washed and unwashed primary eye irritation studies ofstructurally similar read across substanceCyclohexane (CAS No: 110-82-7) performed in six male and female rabbits to assess its eye irritation potential. The chemical was installed into the one of each animal and observations were made 24 hours after treatment. In the unwashed study, at one hour post instillation, corneal opacity, involving up to 25% of the cornea, was noted in one rabbit and iritis was noted in another rabbit. Conjunctival redness was noted in five rabbits with conjunctival chemosis in one rabbit. All ocular lesions had cleared within 24 hours and no conjunctival discharge was noted in any of the six animals. In the washed study, Conjunctival redness (vessels injected above normal) was noted in four rabbits at one hour postinstillation and had cleared by 24 hours. No corneal opacity, iritis, conjunctival chemosis, or discharge 'was noted in any of the six rabbits. Since all the observed effects were cleared within 24 hours, the chemical Cyclohexane (CAS No: 110-82-7) was considered to be non-irritant to the eyes of rabbits.

 

 

 

The above results were further supported by an eye irritation study conducted by OECD SIDS (2008) ofstructurally similar read across substanceNeodecanoyl chloride (CAS no: 40292-82-8) on three rabbits in order to examine the degree of eye irritation caused by the chemical according to Draize method. About 1ml of the neat test substance was appliedinto the conjunctival sac of the rabbit'seye.Eye reactions were examined 24, 48, and 72 hrs after application.Reactions of cornea, iris, and conjunctivae were scored according to the table of Draize.No corneal or iridial reaction was noted in any of the animals at any of the examination intervals.  Slight conjunctival reddening was noted in all rabbits 24 hrs and in one animal 48 hrs after treatment. Changes were reversible and absent on day 3 post treatment.A primary irritation index of 1.3 was calculated for test chemical Neodecanoyl chloride (CAS no: 40292-82-8) and thus can be considered as not irritatingto the eye of rabbits.

 

 

 

Thus on the basis of available data for thetarget chemical3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) andits structurally similar read across substances Cyclohexane (CAS No: 110-82-7)and Neodecanoyl chloride (CAS no: 40292-82-8),it can be concluded thatchemical 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) is unable to cause eye irritation and considered as not irritating.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.

Justification for classification or non-classification

The skin and eye irritation potential of test chemical-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7) and its structurally similar read across substanceswere observed in various studies. The results obtained from these studies indicate that the chemical-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7)is likely to cause skin irritation but not able cause eye irritation. Hence-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No: 52314-67-7)can be classified under the category “Category 2 (irritant)”for skin and “Not Classified” for eye as per CLP.