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Biodegradation in water

Biodegradability of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS no. 52314 -67 -7) is predicted using QSAR toolbox version 3.3 (2017) with logKow as the primary descriptor. Test substance undergoes 14.89% degradation by BOD in 28 days.Thus, based on percentage degradation, the test chemical 3-(2,2-dichloroethenyl) -2,2- dimethylcyclopropane-1-carbonyl chloride was estimated to be not readily biodegradable in water.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-(2,2-dichloroethenyl)-2,2 -dimethylcyclo propane-1-carbonyl chloride (CAS No. 52314 -67 -7). If released in to the environment, 33.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is moderate to high whereas the half-life period of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclo propane-1-carbonyl chloride in sediment is estimated to be 541.66 days (13000 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.168%), indicates that 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride is not persistent in sediment.

Biodegradation in soil

The half-life period of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No. 52314 -67 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 55.7% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of 3-(2,2-dichloro ethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water

Various predicted data for the target compound 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No. 52314-67-7) and supporting weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:

 

In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride(CAS No. 52314-67-7) was estimated.Test substance undergoes 14.89% degradation by BOD in 28 days.Thus, based on percentage degradation, the test chemical 3-(2,2-dichloroethenyl)-2,2- dimethylcyclopropane-1-carbonyl chloride was estimated to be not readily biodegradable in water.

 

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound 3 -(2,2 -dichloroethenyl)-2,2 -dimethylcyclopropane-1 -carbonyl chloride(CAS No. 52314-67-7) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride is expected to be not readily biodegradable.

 

In a supporting weight of evidence study from authoritative database (J-CHECK, 2017 and Envichem, 2014) for the read across chemical 2,2,4,4,6,8,8-heptamethylnonane (CAS no. 4390-04-9), biodegradation experiment was conducted for 14 days for evaluating the percentage biodegradability of read across substance 2,2,4,4,6,8,8-heptamethylnonane. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance 2,2,4,4,6,8,8-heptamethylnonane was determined to be 0% by BOD parameter in 14 days. Thus, based on percentage degradation, 2,2,4,4,6,8,8-heptamethylnonane is considered to be not readily biodegradable in nature.

 

For the another read across chemical 1,1,2-trichloroethene (CAS no. 79-01-6), biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of read across substance 1,1,2-trichloroethene (CAS no. 79-01-6) (J-CHECK, 2017). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance 1,1,2 -trichloroethene was determined to be 2.4 and 0% by BOD and GC parameter in 14 days. Thus, based on percentage degradation, 1,1,2 -trichloroethene is considered to be not readily biodegradable in nature.

 

On the basis of above results for target chemical3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride(from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK and Envichem), it can be concluded that the test substance 3 -(2,2 -dichloroethenyl)-2,2 -dimethylcyclopropane-1 -carbonyl chloride can be expected to be not readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-(2,2-dichloroethenyl)-2,2 -dimethylcyclo propane-1-carbonyl chloride (CAS No. 52314 -67 -7). If released in to the environment, 33.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is moderate to high whereas the half-life period of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclo propane-1-carbonyl chloride in sediment is estimated to be 541.66 days (13000 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.168%), indicates that 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride is not persistent in sediment.

Biodegradation in soil

The half-life period of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride (CAS No. 52314 -67 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 55.7% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of 3-(2,2-dichloro ethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride can be considered to be not readily biodegradable in nature.