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EC number: 257-840-8
CAS number: 52314-67-7
Table 1: Eye Irritation Score Ranges and Means d with Standard Deviations
washed Primary Eye Irritation Study of Cyclohexane in Rabbits
*Mean based on six observations
Table 2: Eye Irritation Score Ranges And Means D With Standard Deviations
Unwashed Primary Eye Irritation Study Of Cyclohexane In Rabbits
Washed and unwashed primary eye
irritation studies of chemical Cyclohexane (CAS No: 110-82-7) was
performed in six male and female rabbits to assess its eye irritation
The chemical was installed into the
one of each animal and observations were made 24 hours after treatment.
In the unwashed study, at one hour
post instillation, corneal opacity, involving up to 25% of the cornea,
was noted in one rabbit and iritis was noted in another rabbit.
Conjunctival redness was noted in five rabbits with conjunctival
chemosis in one rabbit. All ocular lesions had cleared within 24 hours
and no conjunctival discharge was noted in any of the six animals.
In the washed study, Conjunctival
redness (vessels injected above normal) was noted in four rabbits at one
hour postinstillation and had cleared by 24 hours. No corneal opacity,
iritis, conjunctival chemosis, or discharge 'was noted in any of the six
Since all the observed effects were
cleared within 24 hours, the chemical Cyclohexane (CAS No: 110-82-7) was
considered to be non-irritant to the eyes of rabbits.
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