Registration Dossier

Administrative data

Description of key information

Skin Irritation:

The study need not be conducted because the substance is a strong base(pH<=2.0) or strong base (pH=> 11.5).The experimental pH of (3-aminopropyl)(methyl)amine (CAS No: 6291-84-5) was 13.5.

Hence this endpoint was considered for waiver.

Eye Irritation:

The study need not be conducted because the substance is a strong base(pH<=2.0) or strong base (pH=> 11.5).The experimental pH of (3-aminopropyl)(methyl)amine (CAS No: 6291-84-5) was 13.5.

Hence this endpoint was considered for waiver.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin Irritation:

The study need not be conducted because the substance is a strong base(pH<=2.0) or strong base (pH=> 11.5).The experimental pH of (3-aminopropyl)(methyl)amine (CAS No: 6291-84-5) was 13.5.

Hence this endpoint was considered for waiver.

Eye Irritation:

The study need not be conducted because the substance is a strong base(pH<=2.0) or strong base (pH=> 11.5).The experimental pH of (3-aminopropyl)(methyl)amine (CAS No: 6291-84-5) was 13.5.

Hence this endpoint was considered for waiver.

Justification for classification or non-classification

According to the CLP Regulation (EC n. 1272/2008) and based on the high pH of (3-aminopropyl)(methyl)amine (CAS No: 6291-84-5) (pH= 13.5), the classification Skin Corrosive 1 and Eye Damage 1 is proposed for(3-aminopropyl)(methyl)amine (CAS No: 6291-84-5).