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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from NTRL

Data source

Reference
Reference Type:
secondary source
Title:
Initial submission: Letter from Eastman Kodak Co to USEPA Regarding Basictoxicity of 3-methylaminopropylamine with Attachments and Cover Letter dated 9/4/92.
Author:
NTRL
Year:
1992
Bibliographic source:
OTS0555335, NTRL, dated 9/4/92

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute dermal toxicity study of 3-Methylaminopropylamine in Guinea pigs.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
SMILES:CNCCCN
Specific details on test material used for the study:
- Name of test material (as cited in study report): 3-Methylaminopropylamine
- Molecular formula (if other than submission substance): C4H12N2
- Molecular weight (if other than submission substance): 88.1528 g/mole
- Substance type: Organic

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
TEST SITE
- Area of exposure: Clipped backs of abdomen
- % coverage:
- Type of wrap if used: occlusive wrap were used

REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 84.4 to 844 mg/kg
- Concentration (if solution): No data
- Constant volume or concentration used: No data
- For solids, paste formed: No data

VEHICLE
- Amount(s) applied (volume or weight with unit): No data
- Concentration (if solution): No data
- Lot/batch no. (if required): No data
- Purity: No data
Duration of exposure:
24 hours
Doses:
84.4 to 844 mg/kg
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 24 hours
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: Mortality, skin reactions and gross pathology were observed.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 844 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No 50 % mortality observed
Mortality:
Two animals were died after 24 hours
Gross pathology:
Necroses and hemorrhage were observed in treated Guinea pigs.
Other findings:
Skin irritation:
Severe erythema was observed in treated Guinea pigs.

Skin sensitization:
No skin sensitization was observed in treated Guinea pigs.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be >844 mg/kg when Guinea pigs were exposed with 3-aminopropylmethylamine on Clipped backs of abdomen by occlusive wrapping for 24 hours.
Executive summary:

In acute dermal toxicity study,Guinea pigswere exposed with 3-aminopropylmethylamine in the concentration of84.4 to 844 mg/kgonClipped backs of abdomen by occlusive wrappingfor 24 hours.Two animals were died after 24 hours. Necroses and hemorrhage were observed in treated Guinea pigs. Severe erythema was observed in treated Guinea pigs. No skin sensitization was observed in treated Guinea pigs.Therefore,LD50 was considered to be>844 mg/kgwhen Guinea pigs were exposed with3-aminopropylmethylamineonClipped backs of abdomen by occlusive wrappingfor 24 hours.