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EC number: 248-130-9
CAS number: 26952-13-6
a preliminary range finding study, 2 male and 2 female Crl:CD-1TM(1CR)BR
mice were dosed
intraperitoneally at 1000 or 2000 mg/kg body weight and observed for 3
days for clinical signs of toxicity and mortality. There were no signs
of clinical toxicity or mortality observed in either male or female mice
in the range-finding study. Based on a lack of significant difference in
the toxic response to C20-24 alkenes between the sexes, only male mice
were used in the main study.
the main study, C20-24 alkenes was administered to seven male Crl:CD-1TM(1CR)BR
mice intraperitoneally at
500, 1000, or 2000 mg/kg bodyweight. A vehicle control group (arachis
oil, seven male mice) and a positive control group (cyclophosphamide,
five male mice) were also utilized
in the study. Mice were sacrificed at 24 hours. Seven males per group
were exposed to vehicle or 2000 mg/kg and sacrificed at 48 hours. All
animals were observed for signs of toxicity and mortality. Following
sacrifice bone marrow was extracted from the femur; smears were prepared
and subsequently evaluated for an increase in the frequency of
polychromatic erythrocytes (PCEs).
were no signs of clinical toxicity or mortality in male mice dosed with
500, 1000, or 2000 mg/kg in the micronucleus assay. No statistically
significant increases in the number of PCEs or decreases in the PCE/NCE
(normochromatic erythrocytes) ratio were observed in male mice at any
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