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EC number: 248-130-9
CAS number: 26952-13-6
for Read Across:
criteria justify the use of the read across approach to fill data gaps
carbon number isomerised olefinsubstances
using linear alpha olefin substances. Studies indicate that changing the
carbon number, the location of the double bond, or adding branching does
not measurably alter effects on mammalian health endpoints. There
is a consistent toxicity potency pattern for individual alpha olefins
supported by a low toxicity concern for acute oral, dermal and
inhalation exposure. These materials are slightly irritating to skin and
slightly to non-irritating to eyes of rabbits. In repeat dose toxicity
studies, hex-1-ene and tetradec-1 -ene have shown comparable levels of
low toxicity, with female rats exhibiting alterations in body and organ
weights and changes in certain haematological values at the higher doses
tested; male rats exhibiting nephropathy presumed to be associated with
the alpha2u-globulin protein. Screening studies indicate that they are
not neurotoxic (for hex-1-ene and tetradec-1-ene), do not produce
adverse effects on reproduction or foetal development (hex-1-ene and
tetradec-1-ene), and are not genotoxic (hex-1-ene, oct-1-ene, dec-1-ene,
dodec-1-ene, and tetradec-1-ene). Study results for the aforementioned
endpoints indicate a low hazard potential for human health. Since the
addition of branching does not measurably alter the results of studies
on mammalian health endpoints, there should not be any significant toxicological
differences between substances inmultiple
carbon number isomerised olefinsand
linear alpha olefins. Therefore,
read across between these two categories can be justified.
results indicated that 1-octene was efficiently absorbed in the blood
with extensive accumulation in the organs compared to the iso-alkanes. Accumulation
also was shown to increase with increasing carbon number. At
day 3, concentrations of 1-octene were 12.4±0.5, 69.7±4.0, 78.9±9.7,
139.3±23.4, 720±176 µmol/kg in the blood, brain, liver, kidney, and fat,
of 1-decene were 16.4±1.1, 138.1±2.7, 192.8±13.5, 162±22.9, and 2986±305
µmol/kg at day 3 in the blood, brain, liver, kidney, and fat,
of the 1-alkenes remained high in the fat even after the 12 hour
recovery period, with 226±85 µmol/kg of 1-octene and 1971±134 µmol/kg of
to the study authors, the extensive accumulation of 1-alkenes in the
blood and organs when compared to other hydrocarbons may have
toxicological significance and, therefore, products containing 1-alkenes
should be handled cautiously to minimize inhalation exposure.
on study design and results, this
study is classified as reliable with restrictions because while there is
no statement regarding whether this study was conducted according to GLP
or equivalent, the information provided indicates that this study was
conducted in a manner similar to OECD 417 guideline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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