Registration Dossier
Registration Dossier
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EC number: 201-368-7 | CAS number: 81-64-1
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- The influence of dihydroxyanthracene derivatives on water and electrolyte movement in rat colon
- Author:
- Lemmens L, Borja E
- Year:
- 1 976
- Bibliographic source:
- J Pharm Pharmac 28, 498-501 (1976)
Materials and methods
- Principles of method if other than guideline:
- The purgative activities of several dihydroxyanthracene derivatives were onvestigated by determining their influence on the water, sodium and potassium absorption in the gastrointestinal tract by direct injection of the solutions in Tyrode to the rat colon in situ.
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- other: purgative activities of dihydroxyanthracene derivatives
Test material
- Reference substance name:
- 1,4-dihydroxyanthraquinone
- EC Number:
- 201-368-7
- EC Name:
- 1,4-dihydroxyanthraquinone
- Cas Number:
- 81-64-1
- Molecular formula:
- C14H8O4
- IUPAC Name:
- 1,4-dihydroxy-9,10-dihydroanthracene-9,10-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- other: in situ experiment
- Vehicle:
- other: tyrode
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- in situ experiment
- Frequency of treatment:
- in situ experiment
- Post exposure period:
- in situ experiment
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2 ml of a 1mmol/l solution
Basis:
nominal conc.
- No. of animals per sex per dose:
- in situ experiment
- Control animals:
- no
Results and discussion
- Details on results:
- 1,4-dihydroxyanthraquinone did not alter colonic water absorption but restricted sodium absorption and caused release of potassium into the lumen.
Applicant's summary and conclusion
- Executive summary:
The purgative activities of several dihydroxyanthracene derivatives were onvestigated by determining their influence on the water, sodium and potassium absorption in the gastrointestinal tract by direct injection of the solutions in Tyrode to the rat colon in situ.
1,4-dihydroxyanthraquinone did not alter colonic water absorption but restricted sodium absorption and caused release of potassium into the lumen.
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