Registration Dossier
Registration Dossier
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EC number: 201-368-7 | CAS number: 81-64-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- 50 mg test substance was applied into the conjuctival sac of 2 rabbits. Post exposure time was 7 days. Eyes were examinated after application of test substance up to 7 days
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,4-dihydroxyanthraquinone
- EC Number:
- 201-368-7
- EC Name:
- 1,4-dihydroxyanthraquinone
- Cas Number:
- 81-64-1
- Molecular formula:
- C14H8O4
- IUPAC Name:
- 1,4-dihydroxy-9,10-dihydroanthracene-9,10-dione
- Test material form:
- not specified
- Details on test material:
- Chinizarin roh Pt. 229 II
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable - score = 0 at any time point
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other:
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other:
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other:
- Irritant / corrosive response data:
- Chinizarin roh is not irritating to the eyes (cornea score, iris score, conjunctivae score and chemosis score = 0 at 24, 48 and 72 hours).
- Other effects:
- No data
Any other information on results incl. tables
No data.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Chinizarin roh is not irritating to the eyes (cornea score, iris score, conjunctivae score and chemosis score = 0 at 24, 48 and 72 hours). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
- Executive summary:
50 mg test substance was applied into the conjuctival sac of 2 rabbits. Post exposure time was 7 days. Eyes were examinated after application of test substance up to 7 days.
Chinizarin roh is not irritating to the eyes (cornea score, iris score, conjunctivae score and chemosis score = 0 at 24, 48 and 72 hours).
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