1,4-dihydroxyanthraquinone

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Justification for type of information:

The substance has a very low vapour pressure and low dust content.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Version / remarks:

Method B

Deviations:

no

GLP compliance:

no

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Type of method:

sieving

Type of particle tested:

primary particle

Type of distribution:

mass based distribution

Mass median aerodynamic diameter:

14.02 µm

Remarks on result:

other: concerning spherical volume

Key result

Percentile:

D50

Mean:

14.02 µm

Remarks on result:

other: Median diameter corresponds to MMAD (Mass Median Aerodynamic Diameter) as spherical particles.(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)

No.:

#1

Size:

3 - 5 µm

Distribution:

5.92 %

No.:

#2

Size:

5 - 100 µm

Distribution:

93.99 %

The sample was first sieved by a 100 µm sieve:

- weighted sample: 0.77073 g

- weight fraction <100 µm: 0.00114 g

- mass fraction <100 µm: 0.15 %

The mass fraction <100 µm was 0.15 %, and was investigated by scanning electron microscopy. The median aspect ratio was 1.44.

The median diameter of the particle size is given for the fraction <100 µm. The value 14.02 µm was calculated for sherical particles.

Accounting based on the total sample weight
Particle Size	Spherical Volume [%]
<4 µm (respirable)	0.00
4 - 10 µm (thoracic)	0.88
10 - 100 µm (inhalable)	92.70
> 100 µm	6.42
Median (diameter µm)	14.02

   

Conclusions:

The MMAD (Mass Median Aerodynamic Diameter < 100 μm) has a value of 14.02 μm as spherical particles. All particles with a mean diameter less than 100µm have a mass fraction of 0.15 %. 5.92 % of this mass fraction has a mean diameter less than 5 μm.

Executive summary:

According to OECD guideline 110, the particle size distribution of 1,4-dihydroxyanthraquinone was determined by scanning eletron microscopy method for the sieved fration and presented on the basis of calculated mass fractions referring to the total sample weight. All particles with a mean diameter less than 100 µm have a mass fraction of 0.15 %. 5.92 % of this mass fraction has a mean diameter less than 5 μm. The mass mediam diameter is 14.02 µm (spherical volume).

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

no data

GLP compliance:

not specified

Type of method:

other: no data

Temp.:

25 °C

Vapour pressure:

0 Pa

Conclusions:

The vapour pressure of the substance is 0.000133 Pa at 25°C.

Executive summary:

The vapour pressure of the substance is 0.000133 Pa at 25°C.