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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reivewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute oral toxicity in rats
Author:
Gloxhuber et al.
Year:
1978
Bibliographic source:
CLINICAL TOXICOLOGY
Reference Type:
other: authoritative database
Title:
Acute oral toxicity by using test chemical
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus
Reference Type:
review article or handbook
Title:
Acute oral toxicity of test chemical
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials
Reference Type:
review article or handbook
Title:
Acute orl toxicity of test chemical.
Author:
McGraw Hill
Year:
1999
Bibliographic source:
McGraw Hill,1999

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of the given test chemical in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
CAS no.: 91-44-1
EC / List no.: 202-068-9
Name: 7-(diethylamino)-4-methyl-2-benzopyrone
InChI:1S/C14H17NO2/c1-4-15(5-2)11-6-7-12-10(3)8-14(16)17-13(12)9-11/h6-9H,4-5H2,1-3H3
Smiles:c12c(ccc(c1)N(CC)CC)c(cc(=O)o2)C
Molecular formula:C14H17NO2
Molecular weight :231.2933 g/mole
Substance type:Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report): 4-Methyl-7-diethylaminocoumarin
- Molecular formula (if other than submission substance): C14H17NO2
- Molecular weight (if other than submission substance): 231.2933 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
50% mortality was observed in treated rats at 5000 mg/kg bw.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute oral LD50 value was considered to be 5000 mg/kg bw, when rats were treated with the given test chemical orally.
Executive summary:

In a acute oral toxicity study, rats were treated with the given test chemical at the concentration of 5000 mg/kg bw orally. Animals were observed for mortality. 50% mortality was observed in treated rats at 5000 mg/kg bw. Therefore, The acute oral LD50 value was considered to be 5000 mg/kg bw, when rats were treated with the given test chemical orally.