Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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Reaction mass of Pentasodium 2-amino-1-((4-(4-(4-((2-(sulfonatooxy)ethyl)sulfonyl)phenyl)amino-6-chloro-1,3,5-triazin)aminodisulfonatophenyl)diazenyl)-8-hydroxy-naphthalenedisulfonate and Tetrasodium 2-amino-1-((4-(4-(4-(vinylsulfonyl)phenyl)amino-6-chloro-1,3,5-triazin)aminodisulfonatophenyl)diazenyl)-8-hydroxy-naphthalenedisulfonate
EC number: - | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 April 2013 to 19 April 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- (only moistened for good contact)
- Controls:
- no
- Amount / concentration applied:
- 0,5 g
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after removal of the pad
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- , #2
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: one day
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- , #2, #3
- Time point:
- other: 48 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- , #2, #3
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- , #2, #3
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- , #2, #3
- Time point:
- other: 48 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- , #2, #3
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 4
- Other effects:
- A pink coloration of the treatment site, not preventing erythema assessment, was noted in all animals between days 0 and 3. A very slight erythema was noted on the treated area in all animals 1 hour after the patch removal and was totally reversible between days 1 and 2.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item has not to be classified. No signal word or hazard statement is required.
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