Registration Dossier

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Administrative data

Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
5 Aug 2013
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Guideline:
other: REACH guidance on QSARs R.6, May 2008
Principles of method if other than guideline:
Because the test item was expected to have a log Pow lower than 0, the shake-flask method should be used for the determination of the log Pow of Red VP2298. During Non-GLP-Pre-Tests buffer solutions of test item with concentration 1 g/L with pH 2, pH 4 and pH6 were shaken with 1-octanol. Each buffer-phase was coloured, all 1-octanol-phases were uncoloured. Spectra were recorded using a photometer (190 – 1100 nm). The buffer solutions showed an absorption maximum at 529 nm, the 1-octanol-phases did not show any absorption at 529 nm. It is thus concluded, that the concentration of Red VP2298 in the 1-octanol-phase is not determinable using a photometric method. Therefore a calculation of the log Pow was recommended by the study director.
For the calculation of the log POW the program KOWWIN 1.68 (US EPA 2012 Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.10. United States Environmental Protection Agency, Washington, DC, USA) was used.
GLP compliance:
no
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
>= -8.47 - <= -4.44
pH:
6
Remarks on result:
other: generated by KOWIN 1.68

Applicant's summary and conclusion

Conclusions:
The log Pow of the test substance, generated for ionisation states at pH 6 by KOWWIN 1.68 is between -8.47 and -4.44.