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EC number: 300-644-5
CAS number: 93951-21-4
Reactive Blue 250 has low oral toxicity with a LD50 > 5000 mg/kg bw and
has no skin or eye irritating effects. Likewise, the structural analogue
Reactive Black 5 does not have any local irritating or sensitizing
effects in animals. Furthermore, Reactive Black 5 did not show any
adverse effects in the respiratory sensitisation study. However,
respiratory symptoms and/or eczema and urticaria have been reported for
highly exposed workers. As no threshold for this effect is available,
calculation of local DNELs or inhalation DNELs from animal data seemed
not to be reasonable.
Due to the effects reported in highly exposed workers with Reactive
Black 5, Reactive Blue 250 is classified as skin sensitising agent (R43
according to Directive 67/548/EEC and Cat 1 / H317 according to
Regulation 1272/2008/EC) and respiratory sensitizer (R42 according to
Directive 67/548/EEC and Cat 1 / H334 according to Regulation
1272/2008/EC). Based on existing occupational exposure data in textile
manufacturing workers, the operation conditions and risk management
measures indicated in the respective chapters of this CSR are
appropriate and sufficient for controlling the risks.
Due to the chemical reaction of the dye with
the cotton during the dyeing process, Reactive Blue 250 is covalently
bound to the textile. It is therefore unlikely that the consumer is
exposed to the dye from contact to the dyed textile. For home-dyeing,
consumer use is restricted to dyeing with the washing machine (closed
system). The preparation provided for home-dyeing is designed in a way
that exposure of the consumer to the powder can be excluded. A consumer
exposure to Reactive Blue 250 can therefore be excluded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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