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EC number: 201-877-4
CAS number: 89-04-3
RESULTS OF PILOT STUDY: no irritation at concentrations
of 100% test substance
RESULTS OF TEST
- Sensitization reaction: 0/20
- Clinical signs: Local reactions after intradermal
application (test and control animals after 1 and 24 hours): All FCA
treated injections sites showed severe erythema, edema and necrosis. The
animals treated with 10% test substance in maize germ oil showed well
defined erythema and edema.
Local reactions after patch test (48 hours): 1 hour after
patch removal, test and control animals: whole application area showed
erythema and edema, as well as inflamed or bloody lesions, restlessness
of the animals and scratching in the application area.
24 hours after patch removal: Some animals showed
erythema and eschar formation in the whole application area.
A structural analogue of the substance (1,2,4
-Benzenetricarboxylic acid, mixed decyl and octyl triesters) has been
tested for dermal sensitisation in guinea pigs by the Magnusson and
Kligman maximisation test according to OECD guideline 406. No response
was observed at challenge and, on the basis of these results, the
substance was regarded as having no sensitising effect on the skin of
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