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EC number: 201-877-4
CAS number: 89-04-3
- Acute toxicity:Oral: LD50: >2000 mg/kg in the ratDermal: LD50: > 2000 mg/kg in the rat
Acute oral toxicity has been investigated in the rat using methods
described in OECD TG 401. No mortality or effects of treatment occurred
following administration of a single dose at a level of 2000 mg/kg body
weight. The median lethal dose (LD50) in the rat is therefore in excess
of 2000 mg/kg
The acute toxicity of a structural analogue of the
substance (1,2,4 -Benzenetricarboxylic acid, mixed decyl and octyl
triesters) was investigated following dermal administration of a single
dose to the rat at 2000 mg/kg according to OECD guideline 402, adopted
on 24 February 1987 and Test method B.3 "Acute Toxicity (dermal)"
described in Council Regulation (EC) No. 440/2008.
A single dose of 2000 mg/kg was administered to a group of
5 male and 5 female animals for 24 hours. After 14 days all animals were
killed and subjected to necropsy examination. No mortality occurred
following dosing and no signs of toxicity were observed. The body weight
changes observed during the study were within the expected range for
this species and age of animals. No significant abnormalities were found
at necropsy in the animals at termination of the study. No abnormalities
were observed at the treated site.
These results indicated that the test item has no toxic
effect on the rat following dermal exposure over a 24 hour period at a
level of 2000 mg/kg.
The lack of mortality demonstrated the LD50 to be greater
than 2000 mg/kg.
Data are available from a single study for the oral route. Information
for the dermal route has been obtained by read-across from a
structurally related substance, 1,2,4 -benzenetricarboxylic acid with
linear C8- and C10 -alcohols, produced by esterification of trimellitic
anhydride with a mixture of linear C8-C10-alcohols (40 - 60 % C8 and 40
- 60 % C10) rather than C8 alcohol alone. No data are available
regarding inhalation toxicity although the predicted low vapour pressure
suggest exposure to vapours is unlikely and the generation of
significant aerosol concentrations of respirable size during normal use
Classification with regard to acute oral and dermal toxicity is not
justified based on the observed lack of mortality at a dose level of
2000 mg/kg and taking into account the provisions laid down in Council
Directive 67/548/EEC and CLP (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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