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EC number: 204-066-3
CAS number: 115-11-7
There was no effect of isobutylene on the
number, growth or survival of the foetuses in utero.
There was no effect of isobutylene on foetal
development. Although cleft sternebrae were observed
only in foetuses in the isobutylene groups, the incidence of foetuses
affected was small and not dose-related and there were no minor changes
in the appearance or ossification of the sternebrae to indicate that
this area of the skeleton was adversely affected by isobutylene. Also,
there was no evidence for an adverse effect of isobutylene on other
ossification centres of the skeleton. Isolated
differences from control were considered to be incidental. Thus
isobutylene at exposure concentrations of up to 8000 ppm, is considered
not to have any adverse effect on foetal development.
rats were exposed to isobutylene (2-methylpropene) at exposure
concentrations of 500, 2000 and 8000 ppm (1147, 4589, 18359 mg/m3), from
gestation day 5-21. Isobutylene had no effect on the females during
gestation. There was no effect of isobutylene on the number, growth or
survival of the foetuses in utero and no effect on foetal development.
The NOECs for maternal and developmental toxicity were 8000 ppm (18359
mg/m3), the highest concentration tested.
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