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EC number: 204-066-3
CAS number: 115-11-7
female animals (except one animal in the 2000 ppm group) were found
pregnant and delivered live pups. Mating indices for the male rats
treated with the test article were comparable to controls. Mating,
fertility and gestation indices for the female rats treated with the
test article were comparable to controls. Most of the females mated at
the first opportunity. There were also no treatment-related differences
in the other reproductive parameters up to the time of parturition
including the percent of females completing delivery and the duration of
gestation, when compared to controls. There were no treatment related
differences in all parturition parameters including the total number of
pups delivered, the number of pups dying, the viability (4 day survival)
index, the number of implantation sites and corpora lutea per dam, the
pup sex ratio and the number of live pups/litter, when compared to
female rats were exposed to 1-butene at target concentrations of 500,
2000, 8000 ppm (1147, 4589, 18359 mg/m3)
for two weeks prior to breeding, during breeding and until day 19 of
gestation. The dams were then allowed to deliver their litters, which
were retained until post-natal day 4. There was no evidence of systemic
toxicity in the parents.There
were no effects on mating behaviour, fertility and gestation indices,
the number of implantation sites and corpora lutea per dam, numbers of
pups delivered, viability of pups at and after birth and the pup sex
ratio when compared to the control group. Based on these data, the NOAEC
for reproductive toxicity was the highest concentration tested (18359 mg/m3).
There were no treatment-related effects on the development of pups.
There were no effects on body weight gain or observed during macroscopic
examination of pups at post mortem. Based on these data, the NOAEC for
developmental toxicity was also the highest concentration tested (18359 mg/m3).
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