Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study precedes GLP and OECD guidelines, published in peer-reviewed literature, performed to non-standard protocol, but contributing to assessment.

Data source

Reference
Reference Type:
publication
Title:
Range finding toxicity data. (List VII).
Author:
Smyth HF, Carpenter CP, Weil CS, Pozzani US, Striegel JA and Nycum JS.
Year:
1969
Bibliographic source:
Am. Ind. Hyg. Assoc., 30:470-476.

Materials and methods

Principles of method if other than guideline:
Single skin penetration LD50 for rabbits
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Type of coverage:
open
Vehicle:
not specified
Duration of exposure:
4 hours
Doses:
pure substance
No. of animals per sex per dose:
no data
Control animals:
not specified
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1.5 mL/kg bw
Remarks on result:
other: (950 mg/kg bw)

Applicant's summary and conclusion