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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

A GLP-compliant guideline study (EPA-660/3-75-009) is available for propylene oxide, reporting a 96 h LC50 value of 52 mg/L in the freshwater species Salmo gairdneri (new name: Oncorhynchus mykiss) (Shell Research Ltd., 1986). The only saltwater species reported is the common mullet (Mugil cephalus) which shows a similar sensitivity to the freshwater species, having a 96 h LC50 of 89 mg/L (Crews, 1974).

Due to the fact that the substance is considered ready biodegradable, no significant concentrations are present in the water compartment. This is supported by exposure assessment with EUSES. The maximal local PEC value that was calculated was 2.31.10-3mg/L for freshwater and 8.65.10-4mg/L for seawater. Since these concentrations are very low, no significant long term exposure of fish and aquatic invertebrates is assumed and therefore long-term toxicity tests with fish and aquatic invertebrates are not needed.

A GLP-compliant guideline study ( EPA-660/3-75-009) is available for propylene oxide, reporting a 48 h EC50 value of 350 mg/L in the freshwater species Daphnia magna (Shell Research Ltd., 1986).

No long-term aquatic toxicity studies in fish and/or invertebrates are available for propylene oxide.

A GLP-compliant guideline study (EPA-660/3-75-009) is available for propylene oxide reporting a 96 h EC50 value of 240 mg/L based on growth rate in the freshwater species Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata) (Shell Research Ltd., 1986).

There are no toxicity studies available for the effects of propylene oxide on microorganisms. However, there was no measurable inhibition of microbial activity in the closed bottle test (GLP, OECD 301D) at 3 mg/L after 28 days exposure (Shell Research Ltd., 1985).