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Diss Factsheets
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EC number: 203-079-1 | CAS number: 103-09-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials.
- Author:
- Opdyke DL
- Year:
- 1 979
- Bibliographic source:
- Food Cosmet. Toxicol. V, 779, 1979
- Reference Type:
- secondary source
- Title:
- Report to RIFM
- Author:
- Epstein WL
- Year:
- 1 976
- Bibliographic source:
- RIFM no. 76-103, 20 December
- Reference Type:
- secondary source
- Title:
- The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers
- Author:
- Kligman, AM
- Year:
- 1 966
- Bibliographic source:
- J. invest Derm. 47, 393
- Reference Type:
- secondary source
- Title:
- Updating the maximization test for identifying contact allergens
- Author:
- Kligman, AM & Epstein, W
- Year:
- 1 975
- Bibliographic source:
- Contact Dermatitis 1, 231-9
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Maximization test with human volunteers as described in Kligman, AM: The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers, J. invest Derm. 47, 393, 1966 and Kligman, AM & Epstein, W: Updating the maximization test for identifiying contact allergens, Contact Dermatitis 1, 231-9, 1975.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexyl acetate
- EC Number:
- 203-079-1
- EC Name:
- 2-ethylhexyl acetate
- Cas Number:
- 103-09-3
- Molecular formula:
- C10H20O2
- IUPAC Name:
- 2-ethylhexyl acetate
- Details on test material:
- RIFM no . 76-103
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 29
- Clinical history:
- no data
- Controls:
- no data
- Route of administration:
- dermal
- Details on study design:
- Maximization test with human volunteers as described in Kligman, AM: The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers, J. invest Derm. 47, 393, 1966 and Kligman, AM & Epstein, W: Updating the maximization test for identifiying contact allergens, Contact Dermatitis 1, 231-9, 1975.
Results and discussion
- Results of examinations:
- A human maximization study was conducted on 29 healthy subjects. Test materials were applied under occlusion to the same site on the volar forearms of all subjects for 5 alternate day 48 hour periods. Patch sites were pre-tested for 24 hours with 5% aqueous sodium lauryl sulfate (SLS) under occlusion for the initial patch only. Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 5% aqueous SLS under occlusion on the left side of the back whereas the test materials were applied without SLS treatment on the right side. Additional SLS controls were placed on the left and petrolatum on the right and labeled site 5. Vehicle was petrolatum. Questionable reactions were biopsied and followed on a daily basis for 1 week with retest at a separate site at a later time. 4 % 2-ethylhexyl acetate in petrolatum did not produce any skin sensitization reactions.
Any other information on results incl. tables
4 % 2-ethylhexyl acetate in petrolatum did not produce any skin sensitization reactions.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.