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EC number: 268-500-3
CAS number: 68109-88-6
Table 1: Individual Dermal Reactions
Animal no. and sex
Effects noted after initiation of exposure (days)
1 -0 M
3 -0 M
3 -1 M
3 -2 M
3 -3 M
2 -0 F
4 -0 F
4 -1 F
4 -2 F
4 -3 F
0 = no reactions
D = desquamation
Cf = crust formation
Table 2: Individual Bodyweights and Weekly Bodyweight Changes
Bodyweight (g) at day
Bodyweight change (g) during week
The acute dermal toxicity of the test material was investigated in
accordance with the standardised guidelines OECD 402 and EU Method B.3.
During the study, a group of ten animals (five males and five females)
was given a single 24 hour, semi-occluded dermal application of the test
material to intact skin clipped free of hair at a dose level of 2000
mg/kg bw. Clinical signs and bodyweight development were monitored
during the study. All animals were subjected to gross necropsy.
During the study there were no deaths and no signs of systemic toxicity
were observed. One female showed bodyweight loss during the first week
but expected gain in bodyweight during the second week and one female
showed expected gain in bodyweight during the first week but bodyweight
loss during the second week. Remaining animals showed expected gains in
bodyweight over the study period. Signs of dermal irritation noted were
very slight erythema, crust formation and desquamation. There were no
signs of dermal irritation noted at the test site of one male. No
abnormalities were noted at necropsy. The acute dermal median lethal
dose (LD50) of the test material in the Wistar strain rat was
therefore determined to be greater than 2000 mg/kg bw and the test
material requires no classification in accordance with EU criteria.
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