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EC number: 268-500-3
CAS number: 68109-88-6
Table 1 Mortality
Time of Death
In the Group
Hours After Treatment
Days After Treatment
Table 2 Clinical
Table 3 Bodyweights
( ) = Standard deviation
The acute oral toxicity of the test material was evaluated in a study
conducted in accordance with the standardised guideline OECD 401.
Albino rats were administered a single oral dose of the test material by
gavage at dose levels of 1000, 2500 and 5000 mg/kg bodyweight. Five
animals per sex were dosed at each concentration and the animals
observed for 14 days.
Four male and 4 female animals died within 5 days at the 5000 mg/kg
bodyweight dose level. No further mortality was seen. Clinical signs
included sedation, dyspnoea, exophthalmus, ruffled fur and exhibiting a
curved body position. All survivors had recovered by the end of the
observation period and no gross abnormalities were observed at necropsy.
Under the conditions of this study, the LD50 was determined to be 3793
mg/kg bodyweight and the test material requires no classification in
accordance with EU criteria.
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