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EC number: 249-854-8 | CAS number: 29797-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Justification for dichloromethylbenzene in the TRGS 900
Data source
Reference
- Reference Type:
- other: justification for the OEL in the TRGS 900
- Title:
- Begründung zu Dichlormethylbenzol in TRGS 900
- Author:
- Anonymous
- Year:
- 2 016
- Bibliographic source:
- Ausschuss fuer Gefahrstoffe - AGS-Geschäftsführung- BAuA - www.baua.de-
Materials and methods
- Type of study / information:
- Scientific justification for a legally binding occupational threshold value in Germany.
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: scientific expert panel
- Principles of method if other than guideline:
- Scientific justification for a legally binding occupational threshold value in Germany.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dichloromethylbenzene
- EC Number:
- 249-854-8
- EC Name:
- Dichloromethylbenzene
- Cas Number:
- 29797-40-8
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- (dichloromethyl)benzene
- Details on test material:
- not applicable
Constituent 1
Results and discussion
Any other information on results incl. tables
Executive summary
TRGS 900 justification for a legally binding Workplace Exposure Limits in Germany of
8 mg/m³ (1.3 ml/m³); long term
16 mg/m³ (2.6 ml/m³); short term (long term value can be exceeded by a factor of 2)
The dichlorotoluene mixture shows only very low toxicity (oral, dermal, inhalation) after acute administration. It is light to moderately irritating to skin and eyes and has no sensitizing potential in animal experiments on guinea pigs.
In an inhalation hazard test in rats with a saturated vapour atmosphere, at 95°C death occurred after an exposure of 7 hours. The autopsy showed evidence of a slight damage to lungs and liver.
Regarding the question of the toxicity of the dichlorotoluene mixture after repeated application, the results of a subacute oral toxicity study in rats are available.
The NOAEL for males is 100 mg/kg bw/day; in higher doses males revealed a slight hypertrophy of the central lobular hepatocytes, and kidney changes as a result of hyaline droplet accumulation, which manifests itself already in the 20 mg/kg group and which is considered as a species- and gender-specific phenomenon.
In females the NOAEL in this study was 500 mg/kg bw/day.
In the Ames test the dichlorotoluene mixture as well as the pure 2,4-dichlorotoluene is not mutagenic, and in the micronucleus test in mice the dichlorotoluene mixture shows no clastogenic effect .
In the subacute study in rats, there was no evidence of relevant effects on toxicity to reproduction. The effects reported in a publication after oral treatment with 2,4-dichloro-toluene are not taken into account due to the lack of validity of the study.
For the derivation of a guidance value only the results of the subacute oral toxicity study in rats are used. The NOAEL for a human relevant effect is 100 mg/kg bw/day.
Starting from a NOAEL of 100 mg/kg and a total extrapolation factor of 84 results yields a dose of 1.2 mg/kg bw/d. For humans the expert committee derived for a dose of 1.2 mg/kg bw/d, a human body weight of 70 kg and a tidal volume of 10 m³ during 8 hours a Workplace Exposure Limit value of 8 mg/m³.
Accordingly, the Committee derived a Workplace Exposure Limit (ARW) of 1.3 ppm = 8 mg/m³ with a Category II short term limit (long term value can be exceeded by a factor of 2 leading to 16 mg/m³ (2.6 ml/m³); short term). This guidance level is considered as sufficient to ensure the protection of exposed persons to potential hepatotoxic effects of dichlorotoluene mixture.
Applicant's summary and conclusion
- Conclusions:
- TRGS 900 justification for a legally binding Workplace Exposure Limits in Germany of
8 mg/m³ (1.3 ml/m³); long term
16 mg/m³ (2.6 ml/m³); short term (long term value can be exceeded by a factor of 2) - Executive summary:
The available experimental toxicity data were evaluated by the Federal Institute for Occupational Safety and Health (BAuA) for the justification of a legally binding workplace exposure limit in Germany.
Executive summary
TRGS 900 justification for a legally binding Workplace Exposure Limits in Germany of
8 mg/m³ (1.3 ml/m³); long term
16 mg/m³ (2.6 ml/m³); short term (long term value can be exceeded by a factor of 2)
The dichlorotoluene mixture shows only very low toxicity (oral, dermal, inhalation) after acute administration. It is light to moderately irritating to skin and eyes and has no sensitizing potential in animal experiments on guinea pigs.
In an inhalation hazard test in rats with a saturated vapour atmosphere, at 95°C death occurred after an exposure of 7 hours. The autopsy showed evidence of a slight damage to lungs and liver.
Regarding the question of the toxicity of the dichlorotoluene mixture after repeated application, the results of a subacute oral toxicity study in rats are available.
The NOAEL for males is 100 mg/kg bw/day; in higher doses males revealed a slight hypertrophy of the central lobular hepatocytes, and kidney changes as a result of hyaline droplet accumulation, which manifests itself already in the 20 mg/kg group and which is considered as a species- and gender-specific phenomenon.
In females the NOAEL in this study was 500 mg/kg bw/day.
In the Ames test the dichlorotoluene mixture as well as the pure 2,4-dichlorotoluene is not mutagenic, and in the micronucleus test in mice the dichlorotoluene mixture shows no clastogenic effect .
In the subacute study in rats, there was no evidence of relevant effects on toxicity to reproduction. The effects reported in a publication after oral treatment with 2,4-dichloro-toluene are not taken into account due to the lack of validity of the study.
For the derivation of a guidance value only the results of the subacute oral toxicity study in rats are used. The NOAEL for a human relevant effect is 100 mg/kg bw/day.
Starting from a NOAEL of 100 mg/kg and a total extrapolation factor of 84 results yields a dose of 1.2 mg/kg bw/d. For humans the expert committee derived for a dose of 1.2 mg/kg bw/d, a human body weight of 70 kg and a tidal volume of 10 m³ during 8 hours a Workplace Exposure Limit value of 8 mg/m³.
Accordingly, the Committee derived a Workplace Exposure Limit (ARW) of 1.3 ppm = 8 mg/m³ with a Category II short term limit (long term value can be exceeded by a factor of 2 leading to 16 mg/m³ (2.6 ml/m³); short term). This guidance level is considered as sufficient to ensure the protection of exposed persons to potential hepatotoxic effects of dichlorotoluene mixture.
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