Registration Dossier
Registration Dossier
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EC number: 202-851-5 | CAS number: 100-42-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Contact allergy to styrene with cross reaction to vinyltoluene
- Author:
- Sjöborg, S. et al.
- Year:
- 1 982
- Bibliographic source:
- Contact Dermatitis 8: 207-208
- Reference Type:
- secondary source
- Title:
- European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
- Author:
- European Union
- Year:
- 2 007
- Bibliographic source:
- European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
Materials and methods
- Principles of method if other than guideline:
- Guinea pig maximization test. No further details
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- The present study is sufficient to demonstrate the absence of a skin sensitizing potential. A LLNA is therefore not required.
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Styrene
- Analytical purity: no data
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: acetone (challenge)
- Concentration / amount:
- induction: 10% intradermal, 20% topical
challenge: 2% w/v in acetone
Challengeopen allclose all
- Route:
- other: epicutaneous
- Vehicle:
- other: acetone (challenge)
- Concentration / amount:
- induction: 10% intradermal, 20% topical
challenge: 2% w/v in acetone
- No. of animals per dose:
- 15
- Details on study design:
- no details available
- Challenge controls:
- no data
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: no data
- Group:
- test chemical
- Dose level:
- induction: 10% intradermal, 20% topical challenge: 2% w/v in acetone
- No. with + reactions:
- 0
- Total no. in group:
- 15
- Clinical observations:
- no data
- Remarks on result:
- other: Reading: other: no data. Group: test group. Dose level: induction: 10% intradermal, 20% topical challenge: 2% w/v in acetone. No with. + reactions: 0.0. Total no. in groups: 15.0. Clinical observations: no data.
Any other information on results incl. tables
None of the animals were sensitised. No further information available.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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