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EC number: 246-910-3 | CAS number: 25376-45-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 5.9 mg/kg bw/day
Additional information
There were no animal studies on repeated dose toxicity using the oral or dermal route of exposure to commercial mixture of TDA (2,4-/2,6 -TDA, 80/20). For the isomer 2,4-TDA valid long-term feeding studies in rats and mice are available.
Dietary exposure of 2,4-TDA to rats at 5.9 mg/kg bw/day (time-weighted average dose after reduced in food from 125 to 50 ppm) for up to 103 weeks caused a clearly dose related delay of body weight gain and dose related decreased survival rates. At >= 5.9 mg/kg bw/day, hepatotoxic effects, and the development of chronic renal disease were seen, an effect that contributed to a marked decrease in survival of dosed rats. Hepatotoxic effects were shown as focal necrosis of hepatocytes to severe, diffuse, toxic degenerative lesions in the liver (>= 5.9 mg/kg bw/day, long-term study; NCI 1979, Cardy 1979). Kidney lesions were observed in both sexes (most marked in males) at >= 5.9 mg/kg bw/day. Corresponding to the renal disease was a high incidence of associated secondary hyperparathyroidism in dosed males (long-term study; NCI 1979). In addition, hepatocellular carcinomas or neoplastic nodules occurred at incidences that were dose related in both male and the female rats (NCI 1979, Cardy 1979). Experimental
data from rat studies demonstrated that 2,4-TDA induced serious health effects consisting of testicular atrophy at 28 mg/kg bw/day for 15 months (Stula & Aftosmis 1976).
The mouse was less sensitive to 2,4-TDA than rats. Mice exposed to dietary levels of 100 ppm (15 mg/kg bw/day) of 2,4-TDA for 101 weeks showed no significant differences in survival compared to the control animals. There was, however, a delay of body weight gain of 25-50%. This effect was dose related except for the low-dose male mice, for which mean body weights were only slightly lower than those of controls. In treated mice, the incidence of hepatic lesions was not increased, and there were no treatment-related findings in the kidneys. Female mice fed 100 or 200 ppm (approx. 15 or 30 mg/kg bw/day) 2,4-TDA for 101 weeks developed a significant number of carcinomas of the liver. Treated mice of both sexes also developed hyperplastic nodules in the liver, but degenerative effects were not observed in mice ingesting 2,4-TDA up to 101 weeks (NCI 1979, Reuber 1979).
For 2,4-TDA a LOAEL of 5.9 mg/kg bw/day (time-weighted average dose after reduced in food from 125 to 50 ppm) was derived from the 2-year feeding study in rats (NCI 1979). A NOAEL was not estimated. Although this long-term feeding study was not in full agreement with the requirements needed for the base set studies of existing chemicals (only two doses tested, no data on haematology and clinical chemistry parameters), it represents the lowest effect level at which relevant toxic effects were observed. At this dosage there were a decreased survival rate, a clear delay in body weight gain, lesions of the liver and kidneys as well as tumors in the liver in high incidences.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; urogenital: kidneys
Justification for classification or non-classification
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