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EC number: 246-910-3 | CAS number: 25376-45-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The Key study (Hanstveit and Oldersma, 1995) carried out according to OECD Guideline 201 and GLP on the freshwater algae Desmodesmus
subspicatus, gave a 72h ErC50 of 140mg/L and a 72h-EbC50 of 39mg/L for 2,6-TDA.
Key value for chemical safety assessment
Additional information
Available data on toxicity to aquatic algae
Four bibliographic references with reliability (2) reported experimental results on toxicity to aquatic algae. Those experimental results were obtained by tests performed according to OECD guideline 201 (Freshwater Alga and Cyanobacteria, Growth inhibition Test), or to experimental procedures similar to this guideline (i.e. DIN 38412), or according to an acceptable scientific methodology. Ecotoxicity values like 72h-EC50 and 96h-EC50 are reported for two freshwater algae species.
Ecotoxicity data on Selenastrum capricornatum
Experimental results were obtained with the 96 -h freshwater green alga growth inhibition tests. The results on Selenastrum capricornatum are the following:
2,4 -TDA: 96h-EbC50=78.1 µmol/L (=9.53 mg/L) (nominal concentration)
2,6-TDA: 96h-EbC50=466.2 µmol/L (=56.9 mg/L) (nominal concentration)
Ecotoxicity data on Desmodesmus subspicatus
Experimental results were obtained by tests performed according to OECD guideline 201 or equivalent to this one. Ecotoxicity values (72h-EC50) measured on a freshwater species (Desmodesmus subspicatus) are the following:
2,4-TDA: 72h-EbC50=126mg/L (nominal concentration)
2,6-TDA: 72h-EyC50=23mg/L ; 72h-ErC50=140mg/L ; 72h-EbC50=39mg/L (measured concentration, GLP)
Conclusion
Sensitivity of the two algae species to both isomers is different. Based on the experimental study conducted according to OECD guideline 201 under GLP, 72h-ErC50 of 140 mg/L and 72h-EbC50 of 39 mg/L are identified as key information for toxicity to freshwater aquatic algae.
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