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EC number: 200-814-8
CAS number: 74-84-0
Members of the Petroleum Gases category show low sub-chronic toxicity and low potential for neurotoxicity. Inhalation exposure is the most relevant route. No significant exposure-related toxicological or neurotoxicological effects have been observed in inhalation studies up to 90 days duration on the C2-C4 alkanes or Liquefied Petroleum Gas (main constituent propane and propene).
dose toxicity data with neurotoxicity assessments are available for the
C2-C4 alkanes. Inhalation exposure is the most relevant route.
systemic toxicity (i.e., no affect on survival, haematological or
clinical chemistry parameters, food consumption, body weight, organ
weight, and histopathology) or neurological effects (as measured by
clinical observations, functional observational battery, and motor
activity) were observed in 6-week studies to GLP-compliant
in which ethane, propane, isobutane, butane and were administered to
rats by inhalation. The NOAEC in all cases were the maximum dose levels
tested (16000, 12000, 9000 and 9000 ppm respectively (equivalent to
19678, 21641, 21394 and 21394 mg/m3 respectively).
(2009) report an OECD 414 study designed to assess the potential
inhalation toxicity of liquefied petroleum gas (LPG, main constituent
propane and propene) when administered via whole-body exposures to rats
for 13 weeks. The assessment included routine toxicology parameters as
well as detailed evaluations of neurotoxicity parameters. Rats were
exposed to 0 (air control), 1000, 5000 or 10000 ppm of LPG, the highest
exposure concentration was selected for safety reasons and approximated
50% of the lower explosive limit.
animals (except one female animal exposed at the 10000 ppm level)
survived to termination. There were no exposure-related differences in
the test substance exposed animals compared to the air control animals.
There were no treatment related effects on functional observational
battery, motor activity parameters or neuropathology. The NOAEC was
of the Petroleum Gases category are flammable gases at room temperature
and therefore dermal and oral exposure is unlikely. They have low
sub-chronic inhalation toxicity and studies which included evaluation of
neurotoxicity parameters indicate low potential for neurotoxicity.
Classification under the DSD or CLP is not warranted.
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