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EC number: 200-814-8
CAS number: 74-84-0
No specific carcinogenicity data are available on the Petroleum Gases, however, their simple chemical structures with no reactive groups and no structural alerts for likely genotoxic carcinogenic activity, together with the conclusion that C1-C4 alkanes are not genotoxic, provide a strong case for concluding that none will show any significant carcinogenic activity.
of Petroleum Gases have a low potential for carcinogenicity and
therefore do not warrant classification under Dir 67/548/EEC or GHS.
are no carcinogenicity studies available for any of the C1 - C4 alkane
gases which comprise the Petroleum Gases category. However, weight of
evidence from subchronic tests (up to 90 days), a consideration of their
simple chemical structures, which have no reactive groups and carry no
alerts for likely genotoxic carcinogenic activity from established
Structure Activity Relationship analysis ( Tennant
RW and Ashby J (1991). Classification according to chemical structure,
mutagenicity to Salmonella and level of carcinogenicity of a further 39
chemicals by the US National Toxicology Program. Mutat Res 257 (3)
together with the conclusion that C1-C4 alkanes are not genotoxic,
provide a strong case for concluding that none will show any significant
carcinogenic activity. Taking
these data into account, together with the general lack of toxicity
across other endpoints, it is considered that there is no justification
for conducting further animal carcinogenicity studies. The
above reasoning leads to the conclusion that Petroleum Gases category
can be considered to have low concern for human carcinogenicity.
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