Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible

Workers - Hazard for the eyes

Additional information - workers

A DNEL for acute toxicity should be derived if an acute hazard leading to acute toxicity (eg. C&L) has been identified and there is a potential for high peak exposures. This is not the case for Petroleum Gases. Dermal and oral studies are not technically feasible as they are gases at room temperature and all show very low toxicity via the inhalation route.

There was an absence of adverse effects relevant to humans in the repeat dose toxicity studies.

No chronic toxicity data are available for any Petroleum Gases, however, weight of evidence from subchronic tests (up to 90 days) and a consideration of their simple chemical structures, which have no reactive groups and carry no alerts for likely genotoxic carcinogenic activity from established Structure Activity Relationship analysis, together with the conclusion that Petroleum Gases are not genotoxic, provide a strong case for concluding that none will show any significant carcinogenic activity.

 

 

 

 

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

A DNEL for acute toxicity should be derived if an acute hazard leading to acute toxicity (eg. C&L) has been identified and there is a potential for high peak exposures. This is not the case for Petroleum Gases. Dermal and oral studies are not technically feasible as they are gases at room temperature and all show very low toxicity via the inhalation route.

There was an absence of adverse effects relevant to humans in the repeat dose toxicity studies.

No chronic toxicity data are available for any Petroleum Gases, however, weight of evidence from subchronic tests (up to 90 days) and a consideration of their simple chemical structures, which have no reactive groups and carry no alerts for likely genotoxic carcinogenic activity from established Structure Activity Relationship analysis, together with the conclusion that Petroleum Gases are not genotoxic, provide a strong case for concluding that none will show any significant carcinogenic activity.