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EC number: 700-700-2 | CAS number: 1369492-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Remarks:
- The acute earthworm toxicity study was conducted solely to comply with a non-EU national registration requirement, and has been provided here in accordance with REACH, Article 22(1)e.
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- From 24 June 2014 to 25 August 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted under a National quality assurance scheme (HJ/T 155-2004) similar to OECD GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: MEP, P.R. China the guidelines for the Testing of Chemical No.207 "Earthworm, acute Toxicity Test"
- Version / remarks:
- Version 2 / 2013
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Version / remarks:
- 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.6200 (Earthworm Subchronic Toxicity Test)
- Version / remarks:
- EPA 712-C-96-167 / April 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: SEPA, the guidelines for Hazard Evaluation of New Chemical Substances, Environmental Protection agency of P.R.C. (HJ/T 154-2004)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- The study was conducted under a National quality assurance scheme (HJ/T 155-2004) similar to OECD GLP.
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on preparation and application of test substrate:
- - Method of mixing into soil (if used): the test item was weight and mixed with fine ground quartz. According to the soil mixture content, 2822.5 g wet artificial soil (dry weight is 2350 g) was weighed and mixed the above mixture of test item. 300 mL distilled water was added to adjust the moisture content to ca. 35% of dry weight.
- Method of application to soil surface (if used): after fully mixing by blender for 40 minutes, four 750 g (753.2 - 753.9 g) of the test medium were weighed and put into its corresponding labeled test container.
- Controls: yes, prepared under identical procedures but did not contain the test item. - Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: Eisenia Foetida
- Source: Chenggong Earthworm raising Farm, Dongli district, Tianjing.
- Age at test initiation (mean and range, SD): More than two months old
- Weight at test initiation (mean and range, SD): 300.9 to 489.5 mg
ACCLIMATION
- Acclimation period: 24 hours
- Health during acclimation (any mortality observed): no mortality observed - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 20.0 - 21.7%
- Moisture:
- 67 to 86%
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): Height 19cm X Lenght: 12cm X width: 9cm
- Amount of soil or substrate: 2350 g
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
Artificial soil:
a) sphagnum peat moss 10%
b) Kaolin clay 20%
c) Quartz sand 68%
d) Calcuim carbonate 2%
OTHER TEST CONDITIONS
- Photoperiod: light was kept continuous
- Light intensity: 418 to 454 Lux
TEST CONCENTRATIONS
The results of the preliminary test showed that the LC50 was greater than 1000 mg/kg dry soil weight. The definitive test was conducted with a limit test with a concentration of 1000 mg/kg dry soil weight. - Nominal and measured concentrations:
- 1000 mg/kg dry soil weight
- Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality at end of exposure period:
no mortality
- Total mass of adults at beginning of test: 0.3859 g ±0.0509
- Total mass of adults at beginning of test: 0.2665 g ±0.0468
During the exposure period, no toxic symptoms was observed. - Validity criteria fulfilled:
- yes
- Conclusions:
- The 14-day LC50 is greater than 1000 mg/kg dry soil weight.
- Executive summary:
The study was performed to assess the acute toxicity of CA4920 to the earthworm.
Based on the results of preliminary test, the definitive study was conducted with a concentration of 1000 mg/kg dry soild weight. a concurrent control group was conducted in parallel. For the test and control groups, 4 replicates were used with 10 worms in each replicate. Artificial soil was used. The test duration was 14 days. After 7 days and 14 days, toxic symptoms were recorded and the mortality was assessed.
Reference
Description of key information
The study was performed to assess the acute toxicity of CA4920 to the earthworm.
Based on the results of preliminary test, the definitive study was conducted with a concentration of 1000 mg/kg dry soild weight. a concurrent control group was conducted in parallel. For the test and control groups, 4 replicates were used with 10 worms in each replicate. Artificial soil was used. The test duration was 14 days. After 7 days and 14 days, toxic symptoms were recorded and the mortality was assessed.
The 14 -day LC50 was found to be greater than 1000 mg/kg dry soil weight.
Key value for chemical safety assessment
Additional information
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