Registration Dossier

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
endocrine system modulation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
22.05.2012 - 25.05.2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: recent study conducted according to reliable in-house protocol

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: according to P. Sohoni and J.P. Sumpter (1998)
Principles of method if other than guideline:
The aim of the study was to determine the androgenic and antiandrogenic potential of (4-nonylphenoxy) acetic acid. The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Andregenie as weil as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
GLP compliance:
no
Type of method:
in vitro

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: (4-nonylphenoxy) acetic acid
- Physical state: Liquid, yellow to brown
- Analytical purity: >99%
- Storage condition of test material: Room temperature

Administration / exposure

Vehicle:
DMSO

Results and discussion

Details on results:
ln this study, the test substance (4-nonylphenoxy) acetic acid showed no androgenic activity in comparison to dihydrotestosterone. ln this study, the test substance (4-nonylphenoxy) acetic acid showed clear antiandrogenic activity from about 10-5 mol/L in comparison to hydroxyflutamide. No cytotoxicity was observed.

Applicant's summary and conclusion