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EC number: 417-790-1
CAS number: 78418-01-6
Table 1: group means for
animals sacrificed at 24 h
Table 2: group means for
animals sacrificed at 48 h
Table 3: group means for animals sacrificed at 72 h
In an in vivo micronucleus test similar to
OECD guideline 474 and in compliance with GLP, mice were exposed to
Mexoryl SAB. In a range finding assay, pairs of male mice were orally
exposed to Mexoryl SAB at concentrations of 50, 320 and 1000 mg/kg
without any critical sign of toxicity. Then, 5 animals/sex/dose/time of
sacrifice were given single dose of 250, 500 and 1000 mg/kg of Mexoryl
SAB by oral gavage and were sacrificed at 24, 48 and 72 h after dosing.
Then bone marrow cells were harvested, stained with Giemsa and analysed
Positive controls (mitomycin C at 4 mg/kg
intraperitoneally) induced an appropriate increase in the number of
polychromatic erythrocytes. Micronuclei were not induced at any tested
concentrations and at any time of sacrifice in control and in Meroxyl
SAB-treated mice despite a decrease in polychromatic
erythrocytes/normochromatic erythrocytes for 1000 mg/kg at 24 h.
Under the test conditions, Mexoryl SAB was
found not to be clastogenic in vivo in mice.
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