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EC number: 417-790-1
CAS number: 78418-01-6
ER 195 was tested for acute dermal toxicity
in Sprague-Dawley rats in a limit dose assay according to OECD guideline
402 in compliance with GLP. Groups of rats (5/sex) were administered a
single dermal dose of ER 195 at 2000 mg/kg bw on clipped skin moistened
with arachis oil using a semi-occlusive patch held in place for 24 h.
Skin was washed with a cotton wool moistened with arachis oil at the end
of the 24-hour exposure period. Examinations for mortality, clinical
signs and body weight gain were performed during a 14-day observation
period. All surviving animals were necropsied at the end of the
observation period. No deaths and clinical signs occurred during the
observation period. Body weight gain was not affected by treatment
(except for one male). At necropsy, macroscopic examination of main
organs showed no abnormalities. The acute dermal combined LD50 was
greater than 2000 mg/kg bw.
Adverse dermal reactions noted were oedema,
blanching and hard, light brown coloured scabs at the site of
application with loss of the upper layers of skin and fur resulting in
Under the test conditions, ER 195 should not
be classified according to the criteria of the Annex VI of the Directive
67/548/EEC and the CLP Regulation (EC)
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