Registration Dossier
Registration Dossier
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EC number: 232-234-6 | CAS number: 7790-94-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity - LC50 in rodents
- Author:
- U.S. National Library of Medicine
- Year:
- 2 003
- Bibliographic source:
- HSDB
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity - Rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Haz-Map
- Reference Type:
- review article or handbook
- Title:
- Acute inhalation toxicity - Test chemical
- Author:
- S D Gangolli
- Year:
- 2 007
- Bibliographic source:
- The Dictionary of Substances and their Effects
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset - Test chemical
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset
- Reference Type:
- other: abstract
- Title:
- Evaluation of the acute toxicity of the compound
- Author:
- Mamleeva et al.
- Year:
- 1 976
- Bibliographic source:
- Gigiena Truda i Okhrana Zdorov'ya Rabochikh v Neftyanoi i Neftekhimicheskoi Promyshlennosti
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute Inhalation toxicity of the given test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Chlorosulphuric acid
- EC Number:
- 232-234-6
- EC Name:
- Chlorosulphuric acid
- Cas Number:
- 7790-94-5
- Molecular formula:
- ClHO3S
- IUPAC Name:
- sulfurochloridic acid
- Details on test material:
- - IUPAC Name: Chlorosulphuric acid
- InChI: 1S/ClHO3S/c1-5(2,3)4/h(H,2,3,4)
- Smiles: S(=O)(=O)(O)Cl
- Molecular formula :ClHO3S
- Molecular weight :116.5239 g/mol
- Substance type:Inorganic
- Physical state:Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 38.5 mg/m3
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- - Frequency of observations and weighing: The animals were observed for clinical signs and mortality.
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 38.5 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 50% mortality was observed.
- Mortality:
- 50% mortality was observed.
- Clinical signs:
- other: Increased relative liver weight, pulmonary oedema and marked irritation of the mucous membranes were seen.
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- The acute inhalation toxicity dose LC50 value was considered to be 38.5 mg/m3, when rats were treated with the given test chemical via inhalation route for 4-hour exposure.
- Executive summary:
Acute inhalation toxicity study of the given test chemical was conducted in rats at the dose concentration of 38.5 mg/m3 via inhalation route for 4-hour exposure. The animals were observed for clinical signs and mortality. 50% mortality was observed. Increased relative liver weight, pulmonary oedema and marked irritation of the mucous membranes were seen. Therefore, LC50 value was considered to be 38.5 mg/m3, when rats were treated with test chemical via inhalation route for 4-hour exposure.
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