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EC number: 201-627-4
CAS number: 85-73-4
is triggered based on available data, according to REGULATION (EC) No
1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on
classification, labelling and packaging of substances and mixtures,
amending and repealing Directives 67/548/EEC and 1999/45/EC, and
amending Regulation (EC) No 1907/2006.
of phthalylsulfathiazole for effects in the environment
major guideline – estimation values (Klimisch 2) are available for
phthalylsulfathiazole, indicates slight toxic effect for all the 3 key
trophic levels (fish, invertebrate and algae). Among the values lower
values which lead to the classification of the substance the value which
have been considered for further calculation (invertebrate) is LC50 =
determining the classification appropriate to phthalylsulfathiazole, it
is necessary to consider all available evidence concerning its
persistence, potential to accumulate and predicted or observed
environmental fate and behaviour that may present a long-term and/or
delayed danger to the structure and/or functioning of aquatic
ecosystems. These points are considered below.
studies are available to demonstrate that phthalylsulfathiazole is non
persistent in nature and so is considered to have rapid biodegradation
in the environment. In other words phthalylsulfathiazole degradation may
therefore be expected to be fast. Thus it can be inferred that
phthalylsulfathiazole is non persistent in character.
is non persistent and so do not satisfy the criteria for classification
as persistent (P).
and measured log Kow values for phthalylsulfathiazole is less
than 4 (Log Kow = -2). The potential for phthalylsulfathiazole to
bioaccumulate in the tissues of organisms that inhabit aquatic or
terrestrial matrices is negligible as the BCF factor for the substance
is less than 1000.
calculated BCF of phthalylsulfathiazole is 5.25 dimensionless and below
the threshold of 2000.
does not satisfy the criterion for classification as bioaccumulative (B).
toxicity values of fish, invertebrates and algae are LC50 = 26.87273
mg/L, EC50 = 19.051 mg/L are EC50 = 19.3344 mg/L, respectively. The
toxicity values of all the trophic levels fall in the criteria for
classification (CLP regulation) and so will qualify for classification
as per the aquatic CLP criteria for classification in category 3.
phthalylsulfathiazole will satisfy for the environmental effects
criterion for classification as toxic (T).
it can be inferred that phthalylsulfathiazole is not P & B (including
vPvB) substance, but will qualify as T.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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