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EC number: 201-627-4
CAS number: 85-73-4
Phototransformation in Air :
The atmospheric oxidation half life of
phthalylsulfathiazole was estimated using level III multimedia model it
indicates that phthalylsulfathiazole is not persistent in air medium as
the half life period of phthalylsulfathiazole in air is only 0.15 days.
From this it is concluded that phthalylsulfathiazole is rapidly
phototransformed in air.
The Hydrolysis rate constant of
phthalylsulfathiazole was estimated to be
0.0000000000342882 cm3/molecule-sec. at half life of 3.743 Hrs.The
estimated half life of the substance indicates that the substance is
Phototransformation in Water :
No experimental data available. As this
study is not a standard information requirement in REACH and there is no
indication from the CSA on the need to investigate further the fate and
behaviour of the substance (Annex X requirement), no further testing is
Phototransformation in Soil :
Biodegradation in Water : Screening Test
Based on level III fugacity model the half
life period of Phthalylsulfathiazole was estimated.
Phthalylsulfathiazole was 50% biodegradable in water in 38 days
(half-life) indicating that phthalylsulfathiazole is readily
biodegradable in water since the half life is less than the threshold of
60 days (to qualify the chemical as persistent)
Biodegradation in Water and sediment :
Based on level III fugacity model the half
life period of phthalylsulfathiazole was estimated.Half life period of
phthalylsulfathiazole in water was estimated to be 38 days while in
sediment it is 340 days.Based on these half life values it is concluded
that phthalylsulfathiazole is readily biodegradable in
water where as it is non biodegradable in sediment. However, since there
is no diffusion of the substance in the sediment as evident from the
reported data (0% in sediment) and hence persistence in the sediment
compartment is not likely to be critical.
Biodegradation in Soil :
Based on QSAR prediction half life period of
phthalylsulfathiazole in Soil was estimated to be 99.2 days
which exceeds the EPA criteria of 60 days
Also from the other weight of evidnece study
it is found that the substance is 50% degradable in 75 days which also
exceeds the EPA criteria of 60 days
on the above information it can be concluded that the substance is not
readily biodegaradable and hence persistent in Soil according to CLPregulation.
Bioaccumulation : Aquatic/Sediment :
The estimated bioconcentration factor (BCF)
for phthalylsulfathiazole by QSAR ,PBT profiler, EPI suit is 5.25
L/kg/wt , 3.2, 3.162 respectively, which does not exceed the EPA
bioconcentration criteria of1000.
on the above valuesit
can be concluded that the substance does not exceed the EPA
bioconcentration criteria of1000 and therefore is non bioaccumulative in
nature according CLPregulation.
Transport and distribution :
Soil Adsorption Coefficient i.e Koc value of
phthalylsulfathiazole was estimated as 685.1 (log Koc : 2.8357) at 25
deg C by means of MCI method. This indicates that phthalylsulfathiazole
will moderately adsorb to the organic carbon fraction of the soil and
will have a slow migration potential to groundwater. The key value of
Koc at 20 deg C is equivalent to 548.08 (log Koc :2.7388 )
Henry's Law Constant :
Henry's Law states that at a constant
temperature, the amount of a given gas that dissolves in a given type
and volume of liquid is directly proportional to the partial pressure of
that gas in equilibrium with that liquid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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