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EC number: 201-627-4
CAS number: 85-73-4
basis of physical observation and using the sense of smell,
phthalylsulfathiazole was found to be an amorphous colourless substance
with characteristics odour
melting point of phthalylsulfathiazole by the capillary method was found
to be 350.4 degC at an atmospheric pressure of 975 hPa. There was no
decomposition & sublimation observed of phthalylsulfathiazole at the
melting point. This melting point value at 101325 Pa is equivalent to
364.14 deg C.
boiling point of phthalylsulfathiazole by the distillation method was
found to be 357.3 degC at the atmospheric pressure of 975 hPa. No
decomposition of phthalylsulfathiazole was observed at the boiling
point. This boiling point value at 101325 Pa is equivalent to 371.31 deg
density of phthalylsulfathiazole by the mass by volume method was found
to be 0.700 g/cm3 at room temperature of 28 °C . This value when
converted into 20 degC is equivalent to 0.5 g/cm3. The supporting study
shows value different from key studies which could be due to difference
in the estimation conditions.
size distribution (Granulometry) :
particle size distribution (granulometry) of phthalylsulfathiazole by
the sieve analysis method was found to be in the range of 75 micrometer
to 500 micrometer. Majority of the particles were found to be in the
size more than 150 (67.15%) - 75 (17.25%) micrometer in size.
pressure of phthalylsulfathiazole was estimated to be
0.00000000000000283 mm Hg at 25 deg C by using Modified Grain Method.
This value when converted to Pascal is equivalent to 0.000000000000377
Pa. The supporting study shows value different from key studies which
could be due to difference in the estimation conditions. However for the
purpose of chemical safety report, key study values shall be considered
experimental value of octanol water partition co-efficient (log Pow) of
phthalylsulfathiazole by Shake flask method was found to be -2 at
temperature 28 degC and pH of 4.87.This value indicates that
phthalylsulfathiazole is relatively hydrophobic in nature.
experimental value of the water solubility of phthalylsulfathiazole was
found to be 400 mg/L at 28 degC indicating that it is moderately soluble
in water.The supporting study shows value different from key studies
which could be due to difference in the estimation conditions However
for the purpose of chemical safety report, key study values shall be
in organic solvents / fat solubility :
method was used to determine the solubility of the substance in organic
solvent. The experimental value of solubility of phthalyl sulfathiazole
in methanol at temperature of 28 degC was observed to be 2300 mg/L
indicating that phthalyl sulfathiazole is soluble in methanol but more
soluble than water. This value at 20 degC is equivalent to 1642.85 mg/l
accordance with Column 2 adaptation statement of REACH Annex VII,
information requirement 7.6, this end point was considered for waiver
since surface activity was not a desired property of
substance phthalylsulfathiazole was found to be non flammable at 975 hPa
atmospheric pressure. Substance does not have the activity of flash even
did not catch fire on being exposed to air at room temperature of 28
degC and atmospheric pressure of 975 hPa. This indicates that
phthalylsulfathiazole is not auto-flammable.
experimental values of flammability, phthalylsulfathiazole ignited when
the flame of bunsen burner having temperature of 950 degC was brought in
contact with it. Thus it can be concluded that phthalylsulfathiazole is
flammable only at high temperature of about 950 degC. However since such
high temperatures are not found under normal circumstances of
transportation and use, phthalyl sulfathiazole was considered
non-flammable for chemical safety assessment.
to theoretical considerations based on chemical structure,
phthalylsulfathiazole does not possess explosive properties. The reason
for this is there are no chemical groups associated with explosive
properties in phthalylsulfathiazole. Thus, as per column 2 of Annex VII
this end point was considered for waiver.
substance, phthalylsulfathiazole was found to have oxidising property
since 30.09 mg of KMnO4 was required for getting the end point of the
redox titration for 100 g of phthalylsulfathiazole. But this property is
not sufficient to classify the substance as oxidising in nature and so
will not be considered for the same.
in organic solvents and identity of relevant degradation products:
was found to be stable in organic solvent dichloro methane and no
degradation products were formed after 24 hours as evident from the
GC-MS chromatogram obtained at 0 hours and that obtained after 24 hours.
average experimental pKa value for phthalylsulfathiazole was found to be
0.00000333666667 at 28 degC indicating that it has dissociating
properties. This value when converted to 20 deg C is equivalent to
point was considered for waiver since viscosity is an inherent property
of a liquid that offers resistance to its flow and phthalylsulfathiazole
is a solid substance and hence this testing was considered
scientifically unjustified for phthalylsulfathiazole.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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